Cefazolin versus Cefazolin plus Metronidazole for Antibiotic Prophylaxis at Cesarean Section

Norman Meyer, Keehn V. Hosier, Kim Scott, Gary H. Lipscomb

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Although prophylactic antibiotic medications have been shown to reduce the incidence of postoperative infectious morbidity after cesarean delivery, the most effective regimens have not been established. The purpose of this investigation was to compare the efficacy and costs of prophylaxis with cefazolin alone with cefazolin plus metronidazole. Methods: Women undergoing cesarean delivery were randomized to prophylaxis with 2 g cefazolin (n = 81) or 1 g cefazolin plus 500 mg metronidazole (n = 79). Postoperative infectious morbidity and the duration of hospitalization in the two groups were compared. Results: Thirty-seven (23%) of 160 patients developed endomyometritis. There was a significant reduction in the number of postoperative infections (14 versus 32%) and hospital days (3.12 versus 4.46) with cefazolin and metronidazole prophylaxis (P = 0.0064 versus P = 0.014) compared with cefazolin alone. The estimated antibiotic prophylaxis cost per person was less with cefazolin and metronidazole than with cefazolin alone ($9.12 versus $26.73). Conclusion: Antibiotic prophylaxis with metronidazole and cefazolin results in fewer postoperative infections, decreased duration of hospitalization, and lower medication cost than cefazolin alone.

Original languageEnglish (US)
Pages (from-to)992-995
Number of pages4
JournalSouthern Medical Journal
Volume96
Issue number10
DOIs
StatePublished - Oct 2003

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Cefazolin
Antibiotic Prophylaxis
Metronidazole
Cesarean Section
Costs and Cost Analysis
Hospitalization
Morbidity
Endometritis
Infection
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cefazolin versus Cefazolin plus Metronidazole for Antibiotic Prophylaxis at Cesarean Section. / Meyer, Norman; Hosier, Keehn V.; Scott, Kim; Lipscomb, Gary H.

In: Southern Medical Journal, Vol. 96, No. 10, 10.2003, p. 992-995.

Research output: Contribution to journalArticle

Meyer, Norman ; Hosier, Keehn V. ; Scott, Kim ; Lipscomb, Gary H. / Cefazolin versus Cefazolin plus Metronidazole for Antibiotic Prophylaxis at Cesarean Section. In: Southern Medical Journal. 2003 ; Vol. 96, No. 10. pp. 992-995.
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