Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases

John Stuart, Arnold Postlethwaite, Alexander S. Townes, Andrew Kang

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and α chains from each of these types of collagen. The culture supernatant fluids were harvested and assayed for lymphocyte-derived chemotactic factor for monocytes. Reactions to one or more of the native collagens was found in 50 per cent (10 of 20) of the patients with rheumatoid arthritis, 20 per cent (two of 10) of the patients with gout and ankylosing spondylitis but in none of the 10 patients with degenerative joint disease or in normal subjects. Reaction to one or more α chains was found in 90 per cent (18 of 20) of the patients with rheumatoid arthritis, 60 per cent (six of 10) of the patients with gout, 50 per cent (five of 10) of the patients with ankylosing spondylitis, 30 per cent (three of 10) of the patients with degenerative joint disease and in 10 per cent of the normal subjects (one of 10). All the reactions were quantitatively stronger in patients with rheumatoid arthritis. These results indicate that patients with rheumatoid arthritis have cell-mediated immunity to homologous native and denatured collagens but that the reaction is not specific for rheumatoid arthritis. Some patients with gout, ankylosing spondylitis and degenerative joint disease also have low levels of immunity.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalThe American Journal of Medicine
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1980

Fingerprint

Rheumatic Diseases
Cellular Immunity
Rheumatoid Arthritis
Collagen
Gout
Ankylosing Spondylitis
Osteoarthritis
Collagen Type III
Collagen Type II
Collagen Type I
Monocytes
Immunity
Blood Cells

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases. / Stuart, John; Postlethwaite, Arnold; Townes, Alexander S.; Kang, Andrew.

In: The American Journal of Medicine, Vol. 69, No. 1, 01.01.1980, p. 13-18.

Research output: Contribution to journalArticle

@article{f80fb662eb994f568f85b6714a7f81e1,
title = "Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases",
abstract = "Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and α chains from each of these types of collagen. The culture supernatant fluids were harvested and assayed for lymphocyte-derived chemotactic factor for monocytes. Reactions to one or more of the native collagens was found in 50 per cent (10 of 20) of the patients with rheumatoid arthritis, 20 per cent (two of 10) of the patients with gout and ankylosing spondylitis but in none of the 10 patients with degenerative joint disease or in normal subjects. Reaction to one or more α chains was found in 90 per cent (18 of 20) of the patients with rheumatoid arthritis, 60 per cent (six of 10) of the patients with gout, 50 per cent (five of 10) of the patients with ankylosing spondylitis, 30 per cent (three of 10) of the patients with degenerative joint disease and in 10 per cent of the normal subjects (one of 10). All the reactions were quantitatively stronger in patients with rheumatoid arthritis. These results indicate that patients with rheumatoid arthritis have cell-mediated immunity to homologous native and denatured collagens but that the reaction is not specific for rheumatoid arthritis. Some patients with gout, ankylosing spondylitis and degenerative joint disease also have low levels of immunity.",
author = "John Stuart and Arnold Postlethwaite and Townes, {Alexander S.} and Andrew Kang",
year = "1980",
month = "1",
day = "1",
doi = "10.1016/0002-9343(80)90494-5",
language = "English (US)",
volume = "69",
pages = "13--18",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Cell-mediated immunity to collagen and collagen α chains in rheumatoid arthritis and other rheumatic diseases

AU - Stuart, John

AU - Postlethwaite, Arnold

AU - Townes, Alexander S.

AU - Kang, Andrew

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and α chains from each of these types of collagen. The culture supernatant fluids were harvested and assayed for lymphocyte-derived chemotactic factor for monocytes. Reactions to one or more of the native collagens was found in 50 per cent (10 of 20) of the patients with rheumatoid arthritis, 20 per cent (two of 10) of the patients with gout and ankylosing spondylitis but in none of the 10 patients with degenerative joint disease or in normal subjects. Reaction to one or more α chains was found in 90 per cent (18 of 20) of the patients with rheumatoid arthritis, 60 per cent (six of 10) of the patients with gout, 50 per cent (five of 10) of the patients with ankylosing spondylitis, 30 per cent (three of 10) of the patients with degenerative joint disease and in 10 per cent of the normal subjects (one of 10). All the reactions were quantitatively stronger in patients with rheumatoid arthritis. These results indicate that patients with rheumatoid arthritis have cell-mediated immunity to homologous native and denatured collagens but that the reaction is not specific for rheumatoid arthritis. Some patients with gout, ankylosing spondylitis and degenerative joint disease also have low levels of immunity.

AB - Peripheral blood mononuclear cells from patients with rheumatoid arthritis, gout, ankylosing spondylitis and degenerative joint disease were cultured in the presence of native types I, II and III collagens and α chains from each of these types of collagen. The culture supernatant fluids were harvested and assayed for lymphocyte-derived chemotactic factor for monocytes. Reactions to one or more of the native collagens was found in 50 per cent (10 of 20) of the patients with rheumatoid arthritis, 20 per cent (two of 10) of the patients with gout and ankylosing spondylitis but in none of the 10 patients with degenerative joint disease or in normal subjects. Reaction to one or more α chains was found in 90 per cent (18 of 20) of the patients with rheumatoid arthritis, 60 per cent (six of 10) of the patients with gout, 50 per cent (five of 10) of the patients with ankylosing spondylitis, 30 per cent (three of 10) of the patients with degenerative joint disease and in 10 per cent of the normal subjects (one of 10). All the reactions were quantitatively stronger in patients with rheumatoid arthritis. These results indicate that patients with rheumatoid arthritis have cell-mediated immunity to homologous native and denatured collagens but that the reaction is not specific for rheumatoid arthritis. Some patients with gout, ankylosing spondylitis and degenerative joint disease also have low levels of immunity.

UR - http://www.scopus.com/inward/record.url?scp=0018896706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018896706&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(80)90494-5

DO - 10.1016/0002-9343(80)90494-5

M3 - Article

VL - 69

SP - 13

EP - 18

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 1

ER -