Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid β-peptide

Shi Du Yan, Alex Roher, Michael Chaney, Berislav Zlokovic, Ann Marie Schmidt, David Stern

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

Insights into factors underlying causes of familial Alzheimer's disease (AD), such as mutant forms of β-amyloid precursor protein and presenilins, and those conferring increased risk of sporadic AD, such as isoforms of apolipoprotein E and polymorphisms of α2-macroglobulin, have been rapidly emerging. However, mechanisms through which amyloid β-peptide (Aβ), the fibrillogenic peptide most closely associated with neurotoxicity in AD, exerts its effects on cellular targets have only been more generally outlined. Late in the course of AD, when Aβ fibrils are abundant, non-specific interactions of amyloid with cellular elements are likely to induce broad cytotoxicity. However, early in AD, when concentrations of Aβ are much lower and extracellular deposits are infrequent, mechanisms underlying cellular dysfunction have not been clearly defined. The key issue in elucidating the means through which Aβ perturbs cellular properties early in AD is the possibility that protective therapy at such times may prevent cytotoxicity at a point when damage is still reversible. This brief review focusses on two cellular cofactors for Aβ-induced cellular perturbation: the cell surface immunoglobulin superfamily molecule RAGE (receptor for advanced glycation endproducts) and ABAD (Aβ binding alcohol dehydrogenase). Although final proof for the involvement of these cofactors in cellular dysfunction in AD must await the results of further in vivo experiments, their increased expression in AD brain, as well as other evidence described below, suggests the possibility of specific pathways for Aβ-induced cellular perturbation which could provide future therapeutic targets. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)145-157
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1502
Issue number1
DOIs
StatePublished - Jul 26 2000
Externally publishedYes

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Amyloid
Alzheimer Disease
Peptides
Apolipoprotein E2
Presenilins
Macroglobulins
B-Cell Antigen Receptors
Amyloid beta-Protein Precursor
Alcohol Dehydrogenase
Protein Isoforms
Brain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

Cite this

Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid β-peptide. / Yan, Shi Du; Roher, Alex; Chaney, Michael; Zlokovic, Berislav; Schmidt, Ann Marie; Stern, David.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1502, No. 1, 26.07.2000, p. 145-157.

Research output: Contribution to journalReview article

Yan, Shi Du ; Roher, Alex ; Chaney, Michael ; Zlokovic, Berislav ; Schmidt, Ann Marie ; Stern, David. / Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid β-peptide. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2000 ; Vol. 1502, No. 1. pp. 145-157.
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