Cellular distribution of the NMDA receptor NR2A/2B subunits in the rat striatum

Quan Chen, Anton Reiner

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Using immunohistochemical double-labeling with a specific antibody recognizing both NR2A and NR2B subunits, we studied the cellular distribution of the NMDA receptor subunit NR2A/2B on all major known striatal neuron types. Among striatal interneurons, our results showed that none of somatostatin interneurons was labeled for NR2A/2B subunits, 56% of parvalbumin interneurons were double-labeled for NR2A/2B, and all identified cholinergic interneurons were labeled for NR2A/2B. Among striatal projection neurons, 95% of striatonigral neurons, 96% of enkephalin-containing neurons, and 98% of calbindin-containing striatal matrix neurons were double-labeled for NR2A/2B. Our studies demonstrate that there is a differential distribution of the NMDA receptor NR2A/2B subunits on striatal neuron types. The paucity of NR2A/2B subunits on NMDA receptors on striatal somatostatin interneurons may confer resistance to NMDA receptor-mediated excitotoxicity on these neurons.

Original languageEnglish (US)
Pages (from-to)346-352
Number of pages7
JournalBrain Research
Volume743
Issue number1-2
DOIs
StatePublished - Dec 1 1996

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Corpus Striatum
Interneurons
Neurons
Somatostatin
N-Methyl-D-Aspartate Receptors
Calbindins
Parvalbumins
Enkephalins
NR2B NMDA receptor
Cholinergic Agents
Antibodies

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Cellular distribution of the NMDA receptor NR2A/2B subunits in the rat striatum. / Chen, Quan; Reiner, Anton.

In: Brain Research, Vol. 743, No. 1-2, 01.12.1996, p. 346-352.

Research output: Contribution to journalArticle

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