Central α2-adrenoceptors and blood pressure regulation in man

Studies with guanfacine (BS100-141) and azepexole (BHT 933)

J. L. Reid, P. C. Rubin, Colin Howden

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The haemodynamic and sedative actions of guanfacine and azepexole, two α2-adrenoceptor agonists, have been examined in hypertensive patients and normotensive subjects, respectively. After oral dosing both drugs lowered supine and erect blood pressure, reduced plasma noradrenaline and caused subjective drowsiness lasting for 6-8 h. The duration of hypotensive action of a single dose of guanfacine was 24-30 h allowing single daily dosing in several patients, while the duration of effect of azepexole was shorter (8 h). After 8-10 weeks treatment with guanfacine was stopped. There was a gradual return of blood pressure to pre-treatment levels over 4 days. Both the sedative effect and the centrally mediated fall in flood pressure appear to result from activation of adrenoceptors of the α2 subtype.

Original languageEnglish (US)
JournalBritish Journal of Clinical Pharmacology
Volume15
Issue numberSuppl. 4
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Guanfacine
Adrenergic Receptors
Blood Pressure
Hypnotics and Sedatives
Sleep Stages
Norepinephrine
Hemodynamics
Pressure
Therapeutics
Pharmaceutical Preparations
azepexole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Central α2-adrenoceptors and blood pressure regulation in man : Studies with guanfacine (BS100-141) and azepexole (BHT 933). / Reid, J. L.; Rubin, P. C.; Howden, Colin.

In: British Journal of Clinical Pharmacology, Vol. 15, No. Suppl. 4, 01.01.1983.

Research output: Contribution to journalArticle

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