Central imidazoline and angiotensin II receptors in cardiovascular responses to chronic cold exposure in rats

Zhongjie Sun, Robert Cade, Cheryl Tatum

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

(1) Chronic exposure to cold (5°C) induced hypertension in rats within one week. (2) Chronic central administration of an I1 imidazoline receptor agonist, rilmenidine, prevented the development of cold-induced hypertension (CIH). (3) Plasma renin activity and urine norepinephrine output were significantly decreased by central administration of rilmenidine during cold acclimation. (4) Pressor response to central injection of angiotensin II (AII) was inhibited by rilmenidine. (5) Thus, activation of central II receptors could prevent the development of CIH and this may be related to inhibition of pressor effect of central AII. This finding reveals possible relationship between central I1 and AII receptors in cardiovascular responses to chronic cold exposure.

Original languageEnglish (US)
Pages (from-to)513-518
Number of pages6
JournalJournal of Thermal Biology
Volume26
Issue number4-5
DOIs
StatePublished - Sep 12 2001

Fingerprint

rilmenidine
Imidazolines
Angiotensin Receptors
angiotensin II
Rats
Angiotensin II
receptors
rats
hypertension
Hypertension
Renin
Norepinephrine
Chemical activation
renin
Acclimatization
Plasmas
chronic exposure
norepinephrine
agonists
acclimation

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

Cite this

Central imidazoline and angiotensin II receptors in cardiovascular responses to chronic cold exposure in rats. / Sun, Zhongjie; Cade, Robert; Tatum, Cheryl.

In: Journal of Thermal Biology, Vol. 26, No. 4-5, 12.09.2001, p. 513-518.

Research output: Contribution to journalArticle

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