Central line placement in patients with and without prophylactic plasma

Gerardo P. Carino, Arseniy Tsapenko, Joseph D. Sweeney

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Central line placement (CLP) is a common life-saving intervention in critically ill patients, and patients with coagulation abnormalities as identified by an abnormal international normalized ratio (INR) may receive prophylactic plasma transfusion before the procedure despite previously published data that such a practice is not efficacious. Over a 14-month period, 287 CLPs were performed in the intensive care unit. The use of plasma preprocedure in patients with an elevated INR was generally discouraged but left to the discretion of the operator. A total of 100 lines were placed in patients with a preprocedure INR greater than 1.5, 27 of whom received prophylactic fresh frozen plasma. Only 1 case of bleeding was observed in a patient with an INR of 3.9, who received fresh frozen plasma preprocedure (0/73 vs 1/27; P = .6). The occurrence of bleeding was very low overall with CLP (0.3%; 95% confidence interval, 0%-2%), and no benefit of prophylactic plasma was observed.

Original languageEnglish (US)
Pages (from-to)529.e9-529.e13
JournalJournal of Critical Care
Volume27
Issue number5
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

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International Normalized Ratio
Hemorrhage
Critical Illness
Intensive Care Units
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Central line placement in patients with and without prophylactic plasma. / Carino, Gerardo P.; Tsapenko, Arseniy; Sweeney, Joseph D.

In: Journal of Critical Care, Vol. 27, No. 5, 01.01.2012, p. 529.e9-529.e13.

Research output: Contribution to journalArticle

Carino, Gerardo P. ; Tsapenko, Arseniy ; Sweeney, Joseph D. / Central line placement in patients with and without prophylactic plasma. In: Journal of Critical Care. 2012 ; Vol. 27, No. 5. pp. 529.e9-529.e13.
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