Centrality measures for the human red blood cell interactome

Anastasia Kurdia, Ovidiu Daescu, Larry Ammann, David Kakhniashvili, Steven Goodman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)

Abstract

The red blood cell or erythrocyte is easily purified, readily available, and has a relatively simple structure. Therefore, it has become a very well studied cell in terms of protein composition and function. RBC proteomic studies performed over the last five years, by several laboratories, have identified 751 proteins within the human erythrocyte. Data describing most of their interactions are also available. This allowed us to assemble a preliminary interactome of the red blood cell. Identifying the role of certain proteins in the development of blood diseases, such as sickle cell disease, remains a challenge. To give future studies the benefit of focusing on a smaller subset of proteins, we consider several measures aimed to computationally establish the relative functional significance of protein members of the interactome.

Original languageEnglish (US)
Title of host publication2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
Pages98-101
Number of pages4
DOIs
StatePublished - 2007
Externally publishedYes
Event2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS - Richardson, TX, United States
Duration: Nov 11 2007Nov 12 2007

Other

Other2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
CountryUnited States
CityRichardson, TX
Period11/11/0711/12/07

Fingerprint

Blood
Erythrocytes
Cells
Proteins
Hematologic Diseases
Sickle Cell Anemia
Proteomics
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Kurdia, A., Daescu, O., Ammann, L., Kakhniashvili, D., & Goodman, S. (2007). Centrality measures for the human red blood cell interactome. In 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS (pp. 98-101). [4454183] https://doi.org/10.1109/EMBSW.2007.4454183

Centrality measures for the human red blood cell interactome. / Kurdia, Anastasia; Daescu, Ovidiu; Ammann, Larry; Kakhniashvili, David; Goodman, Steven.

2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS. 2007. p. 98-101 4454183.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kurdia, A, Daescu, O, Ammann, L, Kakhniashvili, D & Goodman, S 2007, Centrality measures for the human red blood cell interactome. in 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS., 4454183, pp. 98-101, 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS, Richardson, TX, United States, 11/11/07. https://doi.org/10.1109/EMBSW.2007.4454183
Kurdia A, Daescu O, Ammann L, Kakhniashvili D, Goodman S. Centrality measures for the human red blood cell interactome. In 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS. 2007. p. 98-101. 4454183 https://doi.org/10.1109/EMBSW.2007.4454183
Kurdia, Anastasia ; Daescu, Ovidiu ; Ammann, Larry ; Kakhniashvili, David ; Goodman, Steven. / Centrality measures for the human red blood cell interactome. 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS. 2007. pp. 98-101
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