Ceramide signaling in retinal degeneration

Hui Chen, Julie Thu A. Tran, Richard S. Brush, Anisse Saadi, Abul K. Rahman, Man Yu, Douglas Yasumura, Michael T. Matthes, Kelly Ahern, Haidong Yang, Matthew M. LaVail, Nawajes Mandal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Citations (Scopus)

Abstract

Retinal degenerations (RD) are a complex heterogeneous group of diseases in which retinal photoreceptors and the supporting retinal pigment epithelial cells die irreversibly, causing visual loss for millions of people. Mutations on more than 150 genes have been discovered for RD and there are many forms that possess complex etiology involving more than one gene and environmental effect. For years, many have searched for some common intracellular second messenger for these many forms of cell death which could be targeted for therapy. Ceramide is a novel cellular second messenger which signals for apoptosis. Several lines of evidence suggest an integral role of ceramide in photoreceptor apoptosis and cell death. Understanding their role in the pathogenic pathways of retinal degenerative diseases is important for development of targeted therapeutics.

Original languageEnglish (US)
Title of host publicationRetinal Degenerative Diseases
EditorsMatthew LaVail, Robert Anderson, Christian Grimm, John Ash, Joe Hollyfield
Pages553-558
Number of pages6
DOIs
StatePublished - Jan 23 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume723
ISSN (Print)0065-2598

Fingerprint

Retinal Degeneration
Ceramides
Second Messenger Systems
Cell death
Cell Death
Genes
Apoptosis
Retinal Diseases
Photoreceptor Cells
Vertebrate Photoreceptor Cells
Retinal Pigments
Environmental impact
Epithelial Cells
Mutation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chen, H., Tran, J. T. A., Brush, R. S., Saadi, A., Rahman, A. K., Yu, M., ... Mandal, N. (2012). Ceramide signaling in retinal degeneration. In M. LaVail, R. Anderson, C. Grimm, J. Ash, & J. Hollyfield (Eds.), Retinal Degenerative Diseases (pp. 553-558). (Advances in Experimental Medicine and Biology; Vol. 723). https://doi.org/10.1007/978-1-4614-0631-0_70

Ceramide signaling in retinal degeneration. / Chen, Hui; Tran, Julie Thu A.; Brush, Richard S.; Saadi, Anisse; Rahman, Abul K.; Yu, Man; Yasumura, Douglas; Matthes, Michael T.; Ahern, Kelly; Yang, Haidong; LaVail, Matthew M.; Mandal, Nawajes.

Retinal Degenerative Diseases. ed. / Matthew LaVail; Robert Anderson; Christian Grimm; John Ash; Joe Hollyfield. 2012. p. 553-558 (Advances in Experimental Medicine and Biology; Vol. 723).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, H, Tran, JTA, Brush, RS, Saadi, A, Rahman, AK, Yu, M, Yasumura, D, Matthes, MT, Ahern, K, Yang, H, LaVail, MM & Mandal, N 2012, Ceramide signaling in retinal degeneration. in M LaVail, R Anderson, C Grimm, J Ash & J Hollyfield (eds), Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol. 723, pp. 553-558. https://doi.org/10.1007/978-1-4614-0631-0_70
Chen H, Tran JTA, Brush RS, Saadi A, Rahman AK, Yu M et al. Ceramide signaling in retinal degeneration. In LaVail M, Anderson R, Grimm C, Ash J, Hollyfield J, editors, Retinal Degenerative Diseases. 2012. p. 553-558. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-0631-0_70
Chen, Hui ; Tran, Julie Thu A. ; Brush, Richard S. ; Saadi, Anisse ; Rahman, Abul K. ; Yu, Man ; Yasumura, Douglas ; Matthes, Michael T. ; Ahern, Kelly ; Yang, Haidong ; LaVail, Matthew M. ; Mandal, Nawajes. / Ceramide signaling in retinal degeneration. Retinal Degenerative Diseases. editor / Matthew LaVail ; Robert Anderson ; Christian Grimm ; John Ash ; Joe Hollyfield. 2012. pp. 553-558 (Advances in Experimental Medicine and Biology).
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