Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4

Yong Xing Zhou, Mingrui Zhao, Dan Li, Kazuhiro Shimazu, Kazuko Sakata, Chu Xia Deng, Bai Lu

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Smad4 is a central mediator of TGF-β signals, which are known to play essential roles in many biological processes. Using a Cre-loxP approach to overcome early embryonic lethality, we have studied functions of TGF-β/Smad4 signals in the central nervous system (CNS). No obvious deficits were detected in mice carrying the targeted disruption of Smad4 in the CNS. The overall morphology of the hippocampus appeared normal. There was no change in the proliferation of neuronal precursor cells, nor in several forms of synaptic plasticity. In contrast, deletion of Smad4 resulted in a marked decrease in the number of cerebellar Purkinje cells and parvalbumin-positive interneurons. Accompanied by the abnormality in the cerebellum, mutant mice also exhibited significantly increased vertical activity. Thus, our study reveals an unexpected role for Smad4 in cerebellar development and in the control of motor function.

Original languageEnglish (US)
Pages (from-to)42313-42320
Number of pages8
JournalJournal of Biological Chemistry
Volume278
Issue number43
DOIs
StatePublished - Oct 24 2003
Externally publishedYes

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Neurology
Central Nervous System
Biological Phenomena
Parvalbumins
Neuronal Plasticity
Purkinje Cells
Interneurons
Cerebellum
Plasticity
Hippocampus

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Zhou, Y. X., Zhao, M., Li, D., Shimazu, K., Sakata, K., Deng, C. X., & Lu, B. (2003). Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4. Journal of Biological Chemistry, 278(43), 42313-42320. https://doi.org/10.1074/jbc.M308287200

Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4. / Zhou, Yong Xing; Zhao, Mingrui; Li, Dan; Shimazu, Kazuhiro; Sakata, Kazuko; Deng, Chu Xia; Lu, Bai.

In: Journal of Biological Chemistry, Vol. 278, No. 43, 24.10.2003, p. 42313-42320.

Research output: Contribution to journalArticle

Zhou, YX, Zhao, M, Li, D, Shimazu, K, Sakata, K, Deng, CX & Lu, B 2003, 'Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4', Journal of Biological Chemistry, vol. 278, no. 43, pp. 42313-42320. https://doi.org/10.1074/jbc.M308287200
Zhou, Yong Xing ; Zhao, Mingrui ; Li, Dan ; Shimazu, Kazuhiro ; Sakata, Kazuko ; Deng, Chu Xia ; Lu, Bai. / Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4. In: Journal of Biological Chemistry. 2003 ; Vol. 278, No. 43. pp. 42313-42320.
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