Cerebellar glucose metabolism in chronic aphasia

E. Metter, D. Kempler, C. A. Jackson, W. R. Hanson, W. H. Riege, L. R. Camras, J. C. Mazziotta, M. E. Phelps

Research output: Contribution to journalArticle

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Abstract

(18F)-Fluorodeoxyglucose PET was used to compare left/right cerebellar hemispheric glucose metabolism in 37 aphasic patients with left hemisphere lesions and 22 age-matched controls. Sixteen aphasic subjects showed cerebellar symmetry. Twenty-one aphasic subjects were found to have cerebellar metabolic asymmetry, which (1) resulted from an absolute reduction in local cerebral metabolic rates of glucose in the right cerebellar hemisphere; (2) was associated with left < right glucose metabolic asymmetry in the frontal, parietal, caudate, and thalamic regions; (3) was associated with Broca’s region and deep hemisphere structural damage to the internal capsule and basal ganglia; (4) related to reduced functional motor performance, spontaneous speech, naming, reading, and writing; and (5) included all Broca’s aphasia subjects.

Original languageEnglish (US)
Pages (from-to)1599-1606
Number of pages8
JournalNeurology
Volume37
Issue number10
StatePublished - Jan 1 1987

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Aphasia
Glucose
Broca Aphasia
Internal Capsule
Fluorodeoxyglucose F18
Basal Ganglia
Reading

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Metter, E., Kempler, D., Jackson, C. A., Hanson, W. R., Riege, W. H., Camras, L. R., ... Phelps, M. E. (1987). Cerebellar glucose metabolism in chronic aphasia. Neurology, 37(10), 1599-1606.

Cerebellar glucose metabolism in chronic aphasia. / Metter, E.; Kempler, D.; Jackson, C. A.; Hanson, W. R.; Riege, W. H.; Camras, L. R.; Mazziotta, J. C.; Phelps, M. E.

In: Neurology, Vol. 37, No. 10, 01.01.1987, p. 1599-1606.

Research output: Contribution to journalArticle

Metter, E, Kempler, D, Jackson, CA, Hanson, WR, Riege, WH, Camras, LR, Mazziotta, JC & Phelps, ME 1987, 'Cerebellar glucose metabolism in chronic aphasia', Neurology, vol. 37, no. 10, pp. 1599-1606.
Metter E, Kempler D, Jackson CA, Hanson WR, Riege WH, Camras LR et al. Cerebellar glucose metabolism in chronic aphasia. Neurology. 1987 Jan 1;37(10):1599-1606.
Metter, E. ; Kempler, D. ; Jackson, C. A. ; Hanson, W. R. ; Riege, W. H. ; Camras, L. R. ; Mazziotta, J. C. ; Phelps, M. E. / Cerebellar glucose metabolism in chronic aphasia. In: Neurology. 1987 ; Vol. 37, No. 10. pp. 1599-1606.
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