Cerebral Blastomyces dermatitidis infection in a cat

Jo R. Smith, Alfred M. Legendre, William B. Thomas, Casey J. Leblanc, Cathy Lamkin, James S. Avenell, Jonathan Wall, Silke Hecht

Research output: Contribution to journalArticle

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Abstract

Case Description - An 8-year-old domestic shorthair cat was evaluated because of signs of depression, circling, and visual deficits. Clinical Findings - The cat had no cutaneous lesions, and results of an ophthalmologic examination and thoracic radiography were within reference limits. Computed tomography of the brain revealed a mass lesion involving the right parietal, temporal, and occipital lobes; the mass was in broad-based contact with the skull and smoothly marginated and had strong homogenous enhancement after contrast agent administration. During craniectomy, samples of the mass were collected for cytologic and histopathologic evaluations and microbial culture. A diagnosis of Blastomyces dermatitidis-assoclated meningoencephalitis with secondary pyogranulomatous inflammation was made. Treatment and Outcome - Amphotericin B (0.25 mg/kg [0.11 mg/lb], IV) was administered on alternate days (cumulative dose, 1.75 mg/kg [0.8 mg/lb]). To minimize the risk of nephrotoxicosis, assessments of serum biochemical variables (urea nitrogen and creatinine concentrations) and urinalyses were performed at intervals. The third dose of amphotericin B was postponed 48 hours because the cat became azotemic. The cat subsequently received fluconazole (10 mg/kg [4.5 mg/lb], PO, q 12 h) for 5.5 months. Six months after discontinuation of that treatment, the cat appeared healthy and had no signs of relapse. Clinical Relevance - Brain infection with B dermatitidis is typically associated with widespread disseminated disease. The cat of this report had no evidence of systemic disease. Blastomycosis of the CNS should be considered as a differential diagnosis for brain lesions in cats from areas in which B dermatitidis is endemic.

Original languageEnglish (US)
Pages (from-to)1210-1214
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume231
Issue number8
DOIs
StatePublished - Oct 15 2007

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Blastomyces
Blastomyces dermatitidis
Cats
cats
Infection
infection
Amphotericin B
amphotericin B
brain
lesions (animal)
Brain
Thoracic Radiography
Blastomycosis
Occipital Lobe
Parietal Lobe
Meningoencephalitis
blastomycosis
Urinalysis
Fluconazole
Temporal Lobe

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Smith, J. R., Legendre, A. M., Thomas, W. B., Leblanc, C. J., Lamkin, C., Avenell, J. S., ... Hecht, S. (2007). Cerebral Blastomyces dermatitidis infection in a cat. Journal of the American Veterinary Medical Association, 231(8), 1210-1214. https://doi.org/10.2460/javma.231.8.1210

Cerebral Blastomyces dermatitidis infection in a cat. / Smith, Jo R.; Legendre, Alfred M.; Thomas, William B.; Leblanc, Casey J.; Lamkin, Cathy; Avenell, James S.; Wall, Jonathan; Hecht, Silke.

In: Journal of the American Veterinary Medical Association, Vol. 231, No. 8, 15.10.2007, p. 1210-1214.

Research output: Contribution to journalArticle

Smith, JR, Legendre, AM, Thomas, WB, Leblanc, CJ, Lamkin, C, Avenell, JS, Wall, J & Hecht, S 2007, 'Cerebral Blastomyces dermatitidis infection in a cat', Journal of the American Veterinary Medical Association, vol. 231, no. 8, pp. 1210-1214. https://doi.org/10.2460/javma.231.8.1210
Smith JR, Legendre AM, Thomas WB, Leblanc CJ, Lamkin C, Avenell JS et al. Cerebral Blastomyces dermatitidis infection in a cat. Journal of the American Veterinary Medical Association. 2007 Oct 15;231(8):1210-1214. https://doi.org/10.2460/javma.231.8.1210
Smith, Jo R. ; Legendre, Alfred M. ; Thomas, William B. ; Leblanc, Casey J. ; Lamkin, Cathy ; Avenell, James S. ; Wall, Jonathan ; Hecht, Silke. / Cerebral Blastomyces dermatitidis infection in a cat. In: Journal of the American Veterinary Medical Association. 2007 ; Vol. 231, No. 8. pp. 1210-1214.
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