Cerebral cortical control of orbicularis oculi motoneurons

Suzhen Gong, Michael Decuypere, Yu Zhao, Mark Ledoux

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cerebral cortical neural networks associated with eyelid movement play a critical role in facial animation, contribute to the regulation of blink frequency, and help prevent ocular injury. Eyelid closure depends, in part, on motoneurons that innervate the orbicularis oculi (OO) muscles. In this study, OO motoneuron cortical afferents were identified in rhesus monkeys with rabies virus, a retrograde transneuronal tracer. Virus was injected into the right OO muscle and immunohistochemically localized after 4-6 day transport intervals. Labeled motoneurons were limited to dorsal portions of the ipsilateral facial motor nucleus. After 4- and 4.5-day transport intervals, most labeled cortical neurons were localized to ventrolateral premotor (LPMCv), dorsolateral premotor (LPMCd), and motor (M1) cortices. Labeled neurons were more sparsely distributed in supplementary (M2), caudal (M4), and rostral (M3) cingulate motor cortices; the frontal eye fields (FEF); pre-supplementary motor cortex (pre-SMA); somatosensory cortices (areas 3a, 3b, and 1); and prefrontal cortex. At longer transport intervals (5-6 days), labeled neurons increased substantially in LPMCv, LPMCd, M2, M3, M4, pre-SMA, and FEF. Concentrations of labeled neurons also appeared in cortices along the lateral fissure and intraparietal sulcus. Overall, the densest collection of labeled neurons was localized to the caudal junction of LPMCd and LPMCv with M1. Rostral M3 was another focus of OO premotor neurons. Labeled neurons were distributed bilaterally in all motor cortical areas with a modest contralateral predominance for M2, LPMC, and M1. Thus, the cortical control of OO motor activity is distributed bilaterally among multiple motor areas.

Original languageEnglish (US)
Pages (from-to)177-193
Number of pages17
JournalBrain Research
Volume1047
Issue number2
DOIs
StatePublished - Jun 21 2005

Fingerprint

Motor Neurons
Motor Cortex
Neurons
Frontal Lobe
Eyelids
Eye Injuries
Rabies virus
Muscles
Parietal Lobe
Somatosensory Cortex
Gyrus Cinguli
Prefrontal Cortex
Macaca mulatta
Motor Activity
Viruses

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Cerebral cortical control of orbicularis oculi motoneurons. / Gong, Suzhen; Decuypere, Michael; Zhao, Yu; Ledoux, Mark.

In: Brain Research, Vol. 1047, No. 2, 21.06.2005, p. 177-193.

Research output: Contribution to journalArticle

Gong, Suzhen ; Decuypere, Michael ; Zhao, Yu ; Ledoux, Mark. / Cerebral cortical control of orbicularis oculi motoneurons. In: Brain Research. 2005 ; Vol. 1047, No. 2. pp. 177-193.
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