Cerebral Glucose Metabolic Patterns in Alzheimer's Disease

Effect of Gender and Age at Dementia Onset

Gary W. Small, David E. Kuhl, Walter H. Riege, Denson G. Fujikawa, J. Wesson Ashford, E. Metter, John C. Mazziotta

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

No previous study of Alzheimer's disease has, to our knowledge, assessed the effect of both age at dementia onset and gender on cerebral glucose metabolic patterns. To this end, we used positron emission tomography (fludeoxyglucose F 18 method) to study 24 patients with clinical diagnoses of probable Alzheimer's disease. Comparisons of the 13 patients with earlyonset dementia (<;65 years of age) with the 11 patients with lateonset dementia (>65 years of age) revealed significantly lower left parietal metabolic ratios (left posterior parietal region divided by the hemispheric average) in the early-onset group. The metabolic ratio of posterior parietal cortex divided by the relatively disease-stable average of caudate and thalamus also separated patients with early-onset dementia from those with late-onset dementia, but not men from women. Further comparisons between sexes showed that, in all brain regions studied, the 9 postmenopausal women had higher nonweighted mean metabolic rates than the 15 men from the same age group, with hemispheric sex differences of 9% on the right and 7% on the left. These results demonstrate decreased parietal ratios in earlyonset dementia of Alzheimer's disease, independent of a gender effect.

Original languageEnglish (US)
Pages (from-to)527-532
Number of pages6
JournalArchives of General Psychiatry
Volume46
Issue number6
DOIs
StatePublished - Jan 1 1989

Fingerprint

Age of Onset
Dementia
Alzheimer Disease
Glucose
Parietal Lobe
Fluorodeoxyglucose F18
Thalamus
Sex Characteristics
Positron-Emission Tomography
Age Groups
Alzheimer's Disease
Onset
Brain
Parietal

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Cerebral Glucose Metabolic Patterns in Alzheimer's Disease : Effect of Gender and Age at Dementia Onset. / Small, Gary W.; Kuhl, David E.; Riege, Walter H.; Fujikawa, Denson G.; Ashford, J. Wesson; Metter, E.; Mazziotta, John C.

In: Archives of General Psychiatry, Vol. 46, No. 6, 01.01.1989, p. 527-532.

Research output: Contribution to journalArticle

Small, Gary W. ; Kuhl, David E. ; Riege, Walter H. ; Fujikawa, Denson G. ; Ashford, J. Wesson ; Metter, E. ; Mazziotta, John C. / Cerebral Glucose Metabolic Patterns in Alzheimer's Disease : Effect of Gender and Age at Dementia Onset. In: Archives of General Psychiatry. 1989 ; Vol. 46, No. 6. pp. 527-532.
@article{de0ebb6c933c4999b688d87f64094e09,
title = "Cerebral Glucose Metabolic Patterns in Alzheimer's Disease: Effect of Gender and Age at Dementia Onset",
abstract = "No previous study of Alzheimer's disease has, to our knowledge, assessed the effect of both age at dementia onset and gender on cerebral glucose metabolic patterns. To this end, we used positron emission tomography (fludeoxyglucose F 18 method) to study 24 patients with clinical diagnoses of probable Alzheimer's disease. Comparisons of the 13 patients with earlyonset dementia (<;65 years of age) with the 11 patients with lateonset dementia (>65 years of age) revealed significantly lower left parietal metabolic ratios (left posterior parietal region divided by the hemispheric average) in the early-onset group. The metabolic ratio of posterior parietal cortex divided by the relatively disease-stable average of caudate and thalamus also separated patients with early-onset dementia from those with late-onset dementia, but not men from women. Further comparisons between sexes showed that, in all brain regions studied, the 9 postmenopausal women had higher nonweighted mean metabolic rates than the 15 men from the same age group, with hemispheric sex differences of 9{\%} on the right and 7{\%} on the left. These results demonstrate decreased parietal ratios in earlyonset dementia of Alzheimer's disease, independent of a gender effect.",
author = "Small, {Gary W.} and Kuhl, {David E.} and Riege, {Walter H.} and Fujikawa, {Denson G.} and Ashford, {J. Wesson} and E. Metter and Mazziotta, {John C.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1001/archpsyc.1989.01810060047008",
language = "English (US)",
volume = "46",
pages = "527--532",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "6",

}

TY - JOUR

T1 - Cerebral Glucose Metabolic Patterns in Alzheimer's Disease

T2 - Effect of Gender and Age at Dementia Onset

AU - Small, Gary W.

AU - Kuhl, David E.

AU - Riege, Walter H.

AU - Fujikawa, Denson G.

AU - Ashford, J. Wesson

AU - Metter, E.

AU - Mazziotta, John C.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - No previous study of Alzheimer's disease has, to our knowledge, assessed the effect of both age at dementia onset and gender on cerebral glucose metabolic patterns. To this end, we used positron emission tomography (fludeoxyglucose F 18 method) to study 24 patients with clinical diagnoses of probable Alzheimer's disease. Comparisons of the 13 patients with earlyonset dementia (<;65 years of age) with the 11 patients with lateonset dementia (>65 years of age) revealed significantly lower left parietal metabolic ratios (left posterior parietal region divided by the hemispheric average) in the early-onset group. The metabolic ratio of posterior parietal cortex divided by the relatively disease-stable average of caudate and thalamus also separated patients with early-onset dementia from those with late-onset dementia, but not men from women. Further comparisons between sexes showed that, in all brain regions studied, the 9 postmenopausal women had higher nonweighted mean metabolic rates than the 15 men from the same age group, with hemispheric sex differences of 9% on the right and 7% on the left. These results demonstrate decreased parietal ratios in earlyonset dementia of Alzheimer's disease, independent of a gender effect.

AB - No previous study of Alzheimer's disease has, to our knowledge, assessed the effect of both age at dementia onset and gender on cerebral glucose metabolic patterns. To this end, we used positron emission tomography (fludeoxyglucose F 18 method) to study 24 patients with clinical diagnoses of probable Alzheimer's disease. Comparisons of the 13 patients with earlyonset dementia (<;65 years of age) with the 11 patients with lateonset dementia (>65 years of age) revealed significantly lower left parietal metabolic ratios (left posterior parietal region divided by the hemispheric average) in the early-onset group. The metabolic ratio of posterior parietal cortex divided by the relatively disease-stable average of caudate and thalamus also separated patients with early-onset dementia from those with late-onset dementia, but not men from women. Further comparisons between sexes showed that, in all brain regions studied, the 9 postmenopausal women had higher nonweighted mean metabolic rates than the 15 men from the same age group, with hemispheric sex differences of 9% on the right and 7% on the left. These results demonstrate decreased parietal ratios in earlyonset dementia of Alzheimer's disease, independent of a gender effect.

UR - http://www.scopus.com/inward/record.url?scp=0024475357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024475357&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1989.01810060047008

DO - 10.1001/archpsyc.1989.01810060047008

M3 - Article

VL - 46

SP - 527

EP - 532

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 6

ER -