Cerebral metabolic relationships for selected brain regions in Alzheimer's, Huntington's, and Parkinson's diseases

E. Metter, W. H. Riege, M. Kameyama, D. E. Kuhl, M. E. Phelps

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Local CMRGlc values were determined for 13 regions in each hemisphere from tomographs of patients with Alzheimer's, Huntington's, and Parkinson's diseases who were studied using [18F]fluorodeoxyglucose with positron emission computed tomography. Intercorrelations among the 26 regional measures were calculated for each disease state and for normal controls, and were accepted as reliable at p < 0.01, uncorrected for the number of comparisons. The number of reliable correlations was found to be decreased in Parkinson's and Huntington's disease, two primarily subcortical disorders, and increased in Alzheimer's disease, a primarily cortical disorder. The changes suggest that one role of the basal ganglia involves coordinating or pacing the ability of cortical brain regions to function as a unit.

Original languageEnglish (US)
Pages (from-to)500-506
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1984

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Huntington Disease
Parkinson Disease
Alzheimer Disease
Emission-Computed Tomography
Aptitude
Fluorodeoxyglucose F18
Brain
Basal Ganglia
Positron-Emission Tomography

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Cerebral metabolic relationships for selected brain regions in Alzheimer's, Huntington's, and Parkinson's diseases. / Metter, E.; Riege, W. H.; Kameyama, M.; Kuhl, D. E.; Phelps, M. E.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 4, No. 4, 01.01.1984, p. 500-506.

Research output: Contribution to journalArticle

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