Changes in body composition over 8 years in a randomized trial of a lifestyle intervention

The look AHEAD study

Look AHEAD Research Group

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

Original languageEnglish (US)
Pages (from-to)565-572
Number of pages8
JournalObesity
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2015

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Body Composition
Life Style
Fats
Weight Loss
Photon Absorptiometry
Energy Intake
Social Support
Type 2 Diabetes Mellitus
Volunteers
Cohort Studies
Obesity
Exercise
Education

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Changes in body composition over 8 years in a randomized trial of a lifestyle intervention : The look AHEAD study. / Look AHEAD Research Group.

In: Obesity, Vol. 23, No. 3, 01.03.2015, p. 565-572.

Research output: Contribution to journalArticle

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abstract = "Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7{\%} weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100{\%}) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.",
author = "{Look AHEAD Research Group} and Pownall, {Henry J.} and Bray, {George A.} and Wagenknecht, {Lynne E.} and Walkup, {Michael P.} and Stanley Heshka and Hubbard, {Van S.} and James Hill and Kahn, {Steven E.} and Nathan, {David M.} and Schwartz, {Anne V.} and Johnson, {Karen C.} and Brancati, {Frederick L.} and Lee Swartz and Lawrence Cheskin and Clark, {Jeanne M.} and Kerry Stewart and Richard Rubin and Jean Arceci and Suzanne Ball and Jeanne Charleston and Danielle Diggins and Karen Johnson and Joyce Lambert and Kathy Michalski and Dawn Jiggetts and Chanchai Sapun and Bray, {George A.} and Allison Strate and Greenway, {Frank L.} and Ryan, {Donna H.} and Donald Williamson and Timothy Church and Catherine Champagne and Valerie Myers and Jennifer Arceneaux and Kristi Rau and Michelle Begnaud and Barbara Cerniauskas and Crystal Duncan and Helen Guay and Carolyn Johnson and Lisa Jones and Kim Landry and Missy Lingle and Jennifer Perault and Cindy Puckett and Marisa Smith and Lauren Cox and Mathilda Coday and Ebenezer Nyenwe",
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AU - Wagenknecht, Lynne E.

AU - Walkup, Michael P.

AU - Heshka, Stanley

AU - Hubbard, Van S.

AU - Hill, James

AU - Kahn, Steven E.

AU - Nathan, David M.

AU - Schwartz, Anne V.

AU - Johnson, Karen C.

AU - Brancati, Frederick L.

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AU - Cheskin, Lawrence

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AU - Rubin, Richard

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AU - Ball, Suzanne

AU - Charleston, Jeanne

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AU - Lambert, Joyce

AU - Michalski, Kathy

AU - Jiggetts, Dawn

AU - Sapun, Chanchai

AU - Bray, George A.

AU - Strate, Allison

AU - Greenway, Frank L.

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AU - Church, Timothy

AU - Champagne, Catherine

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AU - Rau, Kristi

AU - Begnaud, Michelle

AU - Cerniauskas, Barbara

AU - Duncan, Crystal

AU - Guay, Helen

AU - Johnson, Carolyn

AU - Jones, Lisa

AU - Landry, Kim

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AU - Perault, Jennifer

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N2 - Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

AB - Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual-energy X-ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post-baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity-linked sequelae, a hypothesis that can be tested by future studies of this cohort.

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