Changes in C-reactive protein predict insulin sensitivity in severely obese individuals after weight loss surgery

Nana Gletsu, Edward Lin, Leena Khaitan, Scott A. Lynch, Bruce Ramshaw, Randall Raziano, William E. Torres, Thomas R. Ziegler, Dimitris A. Papanicolaou, C. Daniel Smith

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The production of inflammatory mediators by abdominal adipose tissue may link obesity and insulin resistance. We determined the influence of systemic levels of interleukin-6 and C-reactive protein on insulin sensitivity after weight loss via Roux-en-Y gastric bypass surgery. Severely obese individuals (n = 15) were evaluated at baseline and at 6 months after surgery. Insulin sensitivity was determined by frequently sampled intravenous glucose tolerance testing at the same time points. Visceral and subcutaneous adipose tissue volumes were quantified by computed tomography. Interleukin-6 and C-reactive protein were measured by enzyme-linked immunoassay in plasma and in adipose tissue biopsies. Correlation analysis was used to determine associations between insulin sensitivity and other outcome variables. Significance was set at P < 0.05. Plasma interleukin-6 concentrations were significantly correlated to the IL-6 content of subcutaneous adipose tissue (r = 0.71). At 6 months postsurgery, subcutaneous and visceral adipose tissue volumes were significantly reduced (34.7% and 44.1%, respectively) and insulin sensitivity had improved by 160.9%. Significant longitudinal correlations were found between insulin sensitivity and plasma C-reactive protein (r = -0.61), but not plasma interleukin-6 at 6 months. These findings offer insights that link obesity and insulin resistance via the activity of inflammatory mediators.

Original languageEnglish (US)
Pages (from-to)1119-1128
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume9
Issue number8
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

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C-Reactive Protein
Insulin Resistance
Weight Loss
Interleukin-6
Subcutaneous Fat
Intra-Abdominal Fat
Obesity
Abdominal Fat
Gastric Bypass
Glucose Tolerance Test
Immunoenzyme Techniques
Adipose Tissue
Blood Proteins
Tomography
Biopsy

All Science Journal Classification (ASJC) codes

  • Surgery

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Changes in C-reactive protein predict insulin sensitivity in severely obese individuals after weight loss surgery. / Gletsu, Nana; Lin, Edward; Khaitan, Leena; Lynch, Scott A.; Ramshaw, Bruce; Raziano, Randall; Torres, William E.; Ziegler, Thomas R.; Papanicolaou, Dimitris A.; Smith, C. Daniel.

In: Journal of Gastrointestinal Surgery, Vol. 9, No. 8, 01.11.2005, p. 1119-1128.

Research output: Contribution to journalArticle

Gletsu, N, Lin, E, Khaitan, L, Lynch, SA, Ramshaw, B, Raziano, R, Torres, WE, Ziegler, TR, Papanicolaou, DA & Smith, CD 2005, 'Changes in C-reactive protein predict insulin sensitivity in severely obese individuals after weight loss surgery', Journal of Gastrointestinal Surgery, vol. 9, no. 8, pp. 1119-1128. https://doi.org/10.1016/j.gassur.2005.07.035
Gletsu, Nana ; Lin, Edward ; Khaitan, Leena ; Lynch, Scott A. ; Ramshaw, Bruce ; Raziano, Randall ; Torres, William E. ; Ziegler, Thomas R. ; Papanicolaou, Dimitris A. ; Smith, C. Daniel. / Changes in C-reactive protein predict insulin sensitivity in severely obese individuals after weight loss surgery. In: Journal of Gastrointestinal Surgery. 2005 ; Vol. 9, No. 8. pp. 1119-1128.
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