Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia

Joshua I. Breier, Jenifer Juranek, Andrew Papanicolaou

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A patient with chronic aphasia secondary to unilateral stroke in the left hemisphere underwent language testing, diffusion tensor imaging (DTI), and functional imaging using magnetoencephalography (MEG) at four time points: 3 weeks prior to, immediately prior to, immediately after, and 3 months after Constraint Induced Language Therapy (CILT). Performance on language tests involving visual naming and repetition of spoken sentences improved between the immediately prior to and immediately after CILT testing sessions, but not between the pre-CILT sessions. MEG activation in putative pre-morbid language areas of the left hemisphere and homotopic areas of the right hemisphere increased immediately after therapy, as did integrity within the arcuate fasciculus bilaterally. These changes were not evident between the two pre-CILT sessions. While some of these functional, neurophysiological and structural changes had regressed 3 months after therapy, all remained at or above baseline levels. Results provide evidence for an association between improvement in functional status and the increased integrity within a white matter tract known to be involved in language function and its contralateral homologue, as well as increased neurophysiological activity in areas that have the potential to subserve language function bilaterally.

Original languageEnglish (US)
Pages (from-to)506-517
Number of pages12
JournalNeurocase
Volume17
Issue number6
DOIs
StatePublished - Dec 1 2011

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Language Therapy
Aphasia
Language
Magnetoencephalography
Language Tests
Diffusion Tensor Imaging
Therapeutics
Stroke
Functions of Language
Integrity
Therapy

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia. / Breier, Joshua I.; Juranek, Jenifer; Papanicolaou, Andrew.

In: Neurocase, Vol. 17, No. 6, 01.12.2011, p. 506-517.

Research output: Contribution to journalArticle

Breier, Joshua I. ; Juranek, Jenifer ; Papanicolaou, Andrew. / Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia. In: Neurocase. 2011 ; Vol. 17, No. 6. pp. 506-517.
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