Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings

Kirsten K. Ness, Chenghong Li, Pauline A. Mitby, Gretchen A. Radloff, Ann C. Mertens, Stella M. Davies, Sue Hammond, Gregory Armstrong, Leslie L. Robison

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose. Analysis of biological samples in large cohort studies may provide insight into the mechanism of, and risk factors for, disease onset and progression. Methods. This study describes the methods used to collect biological samples from a large multi-center cohort of childhood cancer survivors and siblings of childhood cancer survivors and evaluates the predictors of a positive response among these individuals. Results. Among survivors, female sex, white race/ethnicity, college graduation, never smoking, accessing the healthcare system in the past 2 years, and having a second malignant neoplasm were the strongest predictors of returning a sample. Among siblings, a similar demographic profile defined those likely to submit the requested sample. Conclusion. To reduce selection bias and increase the value of these samples for future analysis, additional phone calls and reminders targeting non-responders are needed to improve response rates among those least likely to respond to a single mailed request.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalPediatric Blood and Cancer
Volume55
Issue number1
DOIs
StatePublished - Jul 15 2010
Externally publishedYes

Fingerprint

Cheek
Survivors
Siblings
Neoplasms
Second Primary Neoplasms
Selection Bias
Disease Progression
Cohort Studies
Smoking
Demography
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Ness, K. K., Li, C., Mitby, P. A., Radloff, G. A., Mertens, A. C., Davies, S. M., ... Robison, L. L. (2010). Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings. Pediatric Blood and Cancer, 55(1), 165-170. https://doi.org/10.1002/pbc.22513

Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings. / Ness, Kirsten K.; Li, Chenghong; Mitby, Pauline A.; Radloff, Gretchen A.; Mertens, Ann C.; Davies, Stella M.; Hammond, Sue; Armstrong, Gregory; Robison, Leslie L.

In: Pediatric Blood and Cancer, Vol. 55, No. 1, 15.07.2010, p. 165-170.

Research output: Contribution to journalArticle

Ness, KK, Li, C, Mitby, PA, Radloff, GA, Mertens, AC, Davies, SM, Hammond, S, Armstrong, G & Robison, LL 2010, 'Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings', Pediatric Blood and Cancer, vol. 55, no. 1, pp. 165-170. https://doi.org/10.1002/pbc.22513
Ness, Kirsten K. ; Li, Chenghong ; Mitby, Pauline A. ; Radloff, Gretchen A. ; Mertens, Ann C. ; Davies, Stella M. ; Hammond, Sue ; Armstrong, Gregory ; Robison, Leslie L. / Characteristics of responders to a request for a buccal cell specimen among survivors of childhood cancer and their siblings. In: Pediatric Blood and Cancer. 2010 ; Vol. 55, No. 1. pp. 165-170.
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