Characterization of bionanocomposite scaffolds comprised of amine-functionalized single-walled carbon nanotubes crosslinked to an acellular porcine tendon

Corey R. Deeken, Matthew J. Cozad, Sharon L. Bachman, Bruce Ramshaw, Sheila A. Grant

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Carbon nanotubes (CNT) possess many unique electrical and mechanical properties that make them useful for a variety of industrial and biomedical applications. They are especially attractive materials for biomedical applications since their dimensions are similar to components of the extracellular matrix. In this study, amine-functionalized single-walled carbon nanotubes were crosslinked to an acellular porcine diaphragm tendon. The resulting bionanocomposite scaffolds were subjected to a number of materials characterization techniques including a collagenase assay, uniaxial tensile testing, modulated differential scanning calorimetry, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to determine whether the properties of the original extracellular matrix were altered by the treatment processes. A variety of SWCNT concentrations were investigated. While none of the conditions investigated resulted in bionanocomposites with significantly improved physicochemical properties, no detrimental effects were observed due to any of the processing steps. Future studies should be performed to determine if carbon nanotubes can influence cellular adhesion and function in order to promote rapid integration and remodeling.

Original languageEnglish (US)
Pages (from-to)584-594
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume96 A
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

Carbon Nanotubes
Tendons
Single-walled carbon nanotubes (SWCN)
Scaffolds
Amines
Carbon nanotubes
Tensile testing
Collagenases
Diaphragms
Fourier transform infrared spectroscopy
Differential scanning calorimetry
Assays
Electric properties
Adhesion
Mechanical properties
Processing

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

Cite this

Characterization of bionanocomposite scaffolds comprised of amine-functionalized single-walled carbon nanotubes crosslinked to an acellular porcine tendon. / Deeken, Corey R.; Cozad, Matthew J.; Bachman, Sharon L.; Ramshaw, Bruce; Grant, Sheila A.

In: Journal of Biomedical Materials Research - Part A, Vol. 96 A, No. 3, 01.03.2011, p. 584-594.

Research output: Contribution to journalArticle

@article{b6954a67fb5b409abb9c572a18887f09,
title = "Characterization of bionanocomposite scaffolds comprised of amine-functionalized single-walled carbon nanotubes crosslinked to an acellular porcine tendon",
abstract = "Carbon nanotubes (CNT) possess many unique electrical and mechanical properties that make them useful for a variety of industrial and biomedical applications. They are especially attractive materials for biomedical applications since their dimensions are similar to components of the extracellular matrix. In this study, amine-functionalized single-walled carbon nanotubes were crosslinked to an acellular porcine diaphragm tendon. The resulting bionanocomposite scaffolds were subjected to a number of materials characterization techniques including a collagenase assay, uniaxial tensile testing, modulated differential scanning calorimetry, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to determine whether the properties of the original extracellular matrix were altered by the treatment processes. A variety of SWCNT concentrations were investigated. While none of the conditions investigated resulted in bionanocomposites with significantly improved physicochemical properties, no detrimental effects were observed due to any of the processing steps. Future studies should be performed to determine if carbon nanotubes can influence cellular adhesion and function in order to promote rapid integration and remodeling.",
author = "Deeken, {Corey R.} and Cozad, {Matthew J.} and Bachman, {Sharon L.} and Bruce Ramshaw and Grant, {Sheila A.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1002/jbm.a.33014",
language = "English (US)",
volume = "96 A",
pages = "584--594",
journal = "Journal of Biomedical Materials Research - Part A",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Characterization of bionanocomposite scaffolds comprised of amine-functionalized single-walled carbon nanotubes crosslinked to an acellular porcine tendon

AU - Deeken, Corey R.

AU - Cozad, Matthew J.

AU - Bachman, Sharon L.

AU - Ramshaw, Bruce

AU - Grant, Sheila A.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Carbon nanotubes (CNT) possess many unique electrical and mechanical properties that make them useful for a variety of industrial and biomedical applications. They are especially attractive materials for biomedical applications since their dimensions are similar to components of the extracellular matrix. In this study, amine-functionalized single-walled carbon nanotubes were crosslinked to an acellular porcine diaphragm tendon. The resulting bionanocomposite scaffolds were subjected to a number of materials characterization techniques including a collagenase assay, uniaxial tensile testing, modulated differential scanning calorimetry, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to determine whether the properties of the original extracellular matrix were altered by the treatment processes. A variety of SWCNT concentrations were investigated. While none of the conditions investigated resulted in bionanocomposites with significantly improved physicochemical properties, no detrimental effects were observed due to any of the processing steps. Future studies should be performed to determine if carbon nanotubes can influence cellular adhesion and function in order to promote rapid integration and remodeling.

AB - Carbon nanotubes (CNT) possess many unique electrical and mechanical properties that make them useful for a variety of industrial and biomedical applications. They are especially attractive materials for biomedical applications since their dimensions are similar to components of the extracellular matrix. In this study, amine-functionalized single-walled carbon nanotubes were crosslinked to an acellular porcine diaphragm tendon. The resulting bionanocomposite scaffolds were subjected to a number of materials characterization techniques including a collagenase assay, uniaxial tensile testing, modulated differential scanning calorimetry, and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to determine whether the properties of the original extracellular matrix were altered by the treatment processes. A variety of SWCNT concentrations were investigated. While none of the conditions investigated resulted in bionanocomposites with significantly improved physicochemical properties, no detrimental effects were observed due to any of the processing steps. Future studies should be performed to determine if carbon nanotubes can influence cellular adhesion and function in order to promote rapid integration and remodeling.

UR - http://www.scopus.com/inward/record.url?scp=79251470111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251470111&partnerID=8YFLogxK

U2 - 10.1002/jbm.a.33014

DO - 10.1002/jbm.a.33014

M3 - Article

C2 - 21254390

AN - SCOPUS:79251470111

VL - 96 A

SP - 584

EP - 594

JO - Journal of Biomedical Materials Research - Part A

JF - Journal of Biomedical Materials Research - Part A

SN - 1549-3296

IS - 3

ER -