Characterization of bionanocomposite scaffolds comprised of mercaptoethylamine-functionalized gold nanoparticles crosslinked to acellular porcine tissue

Corey R. Deeken, Sharon L. Bachman, Bruce Ramshaw, Sheila A. Grant

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bionanocomposite scaffolds comprised of nanomaterials and the extracellular matrix (ECM) of porcine diaphragm tissue capitalizes on the benefits of utilizing a natural ECM material, while also potentially enhancing physicomechanical properties and biocompatibility through nanomaterials. Gold nanoparticle (AuNP) bionanocomposite scaffolds were subjected to a number of characterization techniques to determine whether the fabrication process negatively impacted the properties of the porcine diaphragm tissue and whether the AuNP improved the properties of the tissue. Tensile testing and differential scanning calorimetry demonstrated that the bionanocomposite possessed improved tensile strength and thermal stability relative to natural tissue. The collagenase assay and Fourier transform infrared spectroscopy additionally confirmed that denaturation of the collagen of the ECM did not occur. The novel bionanocomposite scaffold possessed properties similar to commercially available scaffolds and will be further developed for soft tissue applications such as hernia repair through in vivo studies in an animal model.

Original languageEnglish (US)
Pages (from-to)537-546
Number of pages10
JournalJournal of Materials Science: Materials in Medicine
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Cysteamine
Scaffolds
Gold
Nanoparticles
Swine
Tissue
gold
nanoparticles
Extracellular Matrix
Nanostructures
diaphragms
Diaphragms
Diaphragm
Nanostructured materials
matrix materials
Denaturation
animal models
Tensile Strength
biopolymer denaturation
Herniorrhaphy

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

Characterization of bionanocomposite scaffolds comprised of mercaptoethylamine-functionalized gold nanoparticles crosslinked to acellular porcine tissue. / Deeken, Corey R.; Bachman, Sharon L.; Ramshaw, Bruce; Grant, Sheila A.

In: Journal of Materials Science: Materials in Medicine, Vol. 23, No. 2, 01.02.2012, p. 537-546.

Research output: Contribution to journalArticle

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