Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of Zanamivir on H5N1 infection in mice

Larisa V. Gubareva, Jonathan Mccullers, Richard C. Bethell, Robert G. Webster

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

A recent outbreak of influenza in Hong Kong was caused by a highly virulent virus of avian origin. Concern that the appearance of such a virus in the human population may be a harbinger of a new pandemic has brought increased attention to the issue of antivirals available for treatment of influenza. A/HongKong/156197 (H5N1), the first virus of H5N1 subtype isolated from a human host, is highly virulent in the mouse model and can infect mouse lungs without requiring adaptation. High mortality and evidence of systemic disease, including spread to the brain after intranasal inoculation, are observed. Zanamivir, a novel neuraminidase inhibitor, is effective at decreasing replication of the virus in vitro. In a model of lethal challenge in mice, zanamivir reduces lung titers of the virus and decreases morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1592-1596
Number of pages5
JournalJournal of Infectious Diseases
Volume178
Issue number6
DOIs
StatePublished - Dec 18 1998

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Zanamivir
H5N1 Subtype Influenza A Virus
Hong Kong
Human Influenza
Infection
Viruses
Lung
Mortality
Neuraminidase
Pandemics
Virus Replication
Viral Load
Antiviral Agents
Disease Outbreaks
Morbidity
Brain
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of Zanamivir on H5N1 infection in mice. / Gubareva, Larisa V.; Mccullers, Jonathan; Bethell, Richard C.; Webster, Robert G.

In: Journal of Infectious Diseases, Vol. 178, No. 6, 18.12.1998, p. 1592-1596.

Research output: Contribution to journalArticle

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