Characterization of neutral fragments in tandem mass spectrometry

A unique route to mechanistic and structural information

Michael J. Polce, Sarka Beranova, Michael J. Nold, Chrys Wesdemiotis

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

The neutral species eliminated upon fragmentation of fast-moving mass-selected ions can be directly identified by collisional ionization and detection in neutral fragment reionization (N(f)R) mass spectra. Establishment of the identity of neutral fragments yields valuable insight into the decomposition mechanism of a precursor ion, as demonstrated for fullerene and alkali metal iodide cluster ions as well as metal ion adducts of amino acids. In addition, neutral fragment reionization also provides structural information that may not be available from the complementary ionic fragments alone; this is illustrated in the differentiation of isomeric mononucleotides. The parameters influencing the appearance of N(f)R spectra are discussed and the scope and general applicability of the method are briefly evaluated.

Original languageEnglish (US)
Pages (from-to)1073-1085
Number of pages13
JournalJournal of Mass Spectrometry
Volume31
Issue number10
DOIs
StatePublished - Oct 1 1996

Fingerprint

Mass spectrometry
Ions
Alkali Metals
Fullerenes
Iodides
Ionization
Metal ions
Decomposition
Amino Acids

All Science Journal Classification (ASJC) codes

  • Spectroscopy

Cite this

Characterization of neutral fragments in tandem mass spectrometry : A unique route to mechanistic and structural information. / Polce, Michael J.; Beranova, Sarka; Nold, Michael J.; Wesdemiotis, Chrys.

In: Journal of Mass Spectrometry, Vol. 31, No. 10, 01.10.1996, p. 1073-1085.

Research output: Contribution to journalReview article

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