Characterization of the role of medial prefrontal cortex dopamine receptors in cocaine-induced locomotor activity

C. E. Beyer, Jeffery Steketee

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Medial prefrontal cortex (mPFC) dopamine (DA) modulates the motor-stimulant response to cocaine. The present study examined the specific mPFC DA receptor subtypes that mediate this behavioral response. Intra-mPFC injection of the DA D2-like receptor agonist quinpirole blocked cocaine-induced motor activity, an effect that was prevented by coadministration of the D2 receptor antagonist sulpiride. Intra-mPFC injection of the selective D4 receptor agonist PD 168,077 or the selective D1 receptor agonist SKF 81297 did not alter the motor-stimulant response to cocaine. Finally, it was found that an intermediate dose of quinpirole, which only attenuated cocaine-induced motor activity, was not altered by SKF 81297 coadministration, suggesting a lack of synergy between mPFC D1 and D2 receptors. These results suggest that D2 receptor mechanisms in the mPFC are at least partly responsible for mediating the acute motor-stimulant effects of cocaine.

Original languageEnglish (US)
Pages (from-to)1093-1100
Number of pages8
JournalBehavioral Neuroscience
Volume115
Issue number5
DOIs
StatePublished - Oct 9 2001

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Dopamine Receptors
Locomotion
Prefrontal Cortex
Cocaine
Quinpirole
Motor Activity
Sulpiride
Injections
Dopamine D2 Receptors
Dopamine

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Characterization of the role of medial prefrontal cortex dopamine receptors in cocaine-induced locomotor activity. / Beyer, C. E.; Steketee, Jeffery.

In: Behavioral Neuroscience, Vol. 115, No. 5, 09.10.2001, p. 1093-1100.

Research output: Contribution to journalArticle

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