Chemical typing of porcine systemic amyloid as AA-amyloid

Theo A. Niewold, Charles L. Murphy, Mathilda J.M. Toussaint, Alan Solomon, Erik Gruys

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Systemic AA amyloidosis is frequently reported in a wide variety of domestic and wild animal species. Porcine amyloidosis is rare and the amyloid has not been typed chemically thus far. In the present study, we have extracted porcine amyloid from formalin-fixed tissue sections. By subsequent amino acid sequencing, an N-terminal fragment was obtained identifying porcine systemic amyloid as AA amyloid. The N-terminal sequence had a great homology to bovine and ovine SAA1, suggesting that pig AA amyloid is derived from the systemic isoform of SAA. It is argued that the low incidence of amyloidosis in pigs is not likely to be attributed to unique features of porcine amyloid precursor protein. Elucidation of the basis for the high apparent resistance of pigs against amyloidosis may yield important clues for treatment and prevention of amyloidosis in other species. This is the first report on chemical identification of porcine amyloid.

Original languageEnglish (US)
Pages (from-to)164-166
Number of pages3
JournalAmyloid
Volume12
Issue number3
DOIs
StatePublished - Sep 1 2005

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Amyloid
Swine
Amyloidosis
Wild Animals
Amyloid beta-Protein Precursor
Protein Sequence Analysis
Domestic Animals
Formaldehyde
Sheep
Protein Isoforms
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Niewold, T. A., Murphy, C. L., Toussaint, M. J. M., Solomon, A., & Gruys, E. (2005). Chemical typing of porcine systemic amyloid as AA-amyloid. Amyloid, 12(3), 164-166. https://doi.org/10.1080/13506120500231806

Chemical typing of porcine systemic amyloid as AA-amyloid. / Niewold, Theo A.; Murphy, Charles L.; Toussaint, Mathilda J.M.; Solomon, Alan; Gruys, Erik.

In: Amyloid, Vol. 12, No. 3, 01.09.2005, p. 164-166.

Research output: Contribution to journalArticle

Niewold, TA, Murphy, CL, Toussaint, MJM, Solomon, A & Gruys, E 2005, 'Chemical typing of porcine systemic amyloid as AA-amyloid', Amyloid, vol. 12, no. 3, pp. 164-166. https://doi.org/10.1080/13506120500231806
Niewold, Theo A. ; Murphy, Charles L. ; Toussaint, Mathilda J.M. ; Solomon, Alan ; Gruys, Erik. / Chemical typing of porcine systemic amyloid as AA-amyloid. In: Amyloid. 2005 ; Vol. 12, No. 3. pp. 164-166.
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