Chemoenzymatic synthesis of Park's nucleotide

toward the development of high-throughput screening for MraY inhibitors

Michio Kurosu, Sebabrata Mahapatra, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

An efficient chemoenzymatic synthesis of UDP-N-acetylmuramyl-l-alanyl-γ-d-glutamyl-meso-diaminopimelyl-d-alanyl-d-alanine (Park's nucleotide) is reported. UDP-MurNAc is efficiently synthesized by a minimum number of protecting strategies. One-pot amino acid ligation reactions catalyzed by MurC, D, E, and F enzymes are amenable to scale-up production.

Original languageEnglish (US)
Pages (from-to)799-803
Number of pages5
JournalTetrahedron Letters
Volume48
Issue number5
DOIs
StatePublished - Jan 29 2007
Externally publishedYes

Fingerprint

Uridine Diphosphate
Screening
Nucleotides
Throughput
Alanine
Ligation
Amino Acids
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Chemoenzymatic synthesis of Park's nucleotide : toward the development of high-throughput screening for MraY inhibitors. / Kurosu, Michio; Mahapatra, Sebabrata; Narayanasamy, Prabagaran; Crick, Dean C.

In: Tetrahedron Letters, Vol. 48, No. 5, 29.01.2007, p. 799-803.

Research output: Contribution to journalArticle

Kurosu, Michio ; Mahapatra, Sebabrata ; Narayanasamy, Prabagaran ; Crick, Dean C. / Chemoenzymatic synthesis of Park's nucleotide : toward the development of high-throughput screening for MraY inhibitors. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 5. pp. 799-803.
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