CHF

Circulatory homeostasis gone awry

Karl Weber, Brad S. Burlew, Richard C. Davis, Kevin P. Newman, Ivan A. D'Cruz, Ralph G. Hawkins, Barry Wall, Robert Parker

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The role of the renin-angiotensin-aldosterone system (RAAS) is integral to salt and water retention, particularly by the kidneys. Over time, positive sodium balance leads first to intra- and then to extravascular volume expansion, with subsequent symptomatic heart failure. This report examines the role of the RAAS in regulating a less well recognized component essential to circulatory homeostasis - central blood volume. The regulation of central blood volume draws on integrative cardiorenal physiology and a key role played by the RAAS in its regulation. In presenting insights into the role of the RAAS in regulating central blood volume, this review also addresses other sodium-retaining states with a predisposition to edema formation, such as cirrhosis and nephrosis.

Original languageEnglish (US)
Pages (from-to)37-48
Number of pages12
JournalCongestive Heart Failure
Volume8
Issue number1
StatePublished - May 11 2002

Fingerprint

Renin-Angiotensin System
Homeostasis
Blood Volume
Sodium
Nephrosis
Edema
Fibrosis
Heart Failure
Salts
Kidney
Water

All Science Journal Classification (ASJC) codes

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

Weber, K., Burlew, B. S., Davis, R. C., Newman, K. P., D'Cruz, I. A., Hawkins, R. G., ... Parker, R. (2002). CHF: Circulatory homeostasis gone awry. Congestive Heart Failure, 8(1), 37-48.

CHF : Circulatory homeostasis gone awry. / Weber, Karl; Burlew, Brad S.; Davis, Richard C.; Newman, Kevin P.; D'Cruz, Ivan A.; Hawkins, Ralph G.; Wall, Barry; Parker, Robert.

In: Congestive Heart Failure, Vol. 8, No. 1, 11.05.2002, p. 37-48.

Research output: Contribution to journalReview article

Weber, K, Burlew, BS, Davis, RC, Newman, KP, D'Cruz, IA, Hawkins, RG, Wall, B & Parker, R 2002, 'CHF: Circulatory homeostasis gone awry', Congestive Heart Failure, vol. 8, no. 1, pp. 37-48.
Weber K, Burlew BS, Davis RC, Newman KP, D'Cruz IA, Hawkins RG et al. CHF: Circulatory homeostasis gone awry. Congestive Heart Failure. 2002 May 11;8(1):37-48.
Weber, Karl ; Burlew, Brad S. ; Davis, Richard C. ; Newman, Kevin P. ; D'Cruz, Ivan A. ; Hawkins, Ralph G. ; Wall, Barry ; Parker, Robert. / CHF : Circulatory homeostasis gone awry. In: Congestive Heart Failure. 2002 ; Vol. 8, No. 1. pp. 37-48.
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