Childhood vaccinations and risk of asthma

Frank Destefano, David Gu, Piotr Kramarz, Benedict I. Truman, Michael F. Iademarco, John P. Mullooly, Lisa A. Jackson, Robert Davis, Steven B. Black, Henry R. Shinefield, S. Michael Marcy, Joel I. Ward, Robert T. Chen

Research output: Contribution to journalArticle

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Abstract

Background. A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma. Methods. Cohort study involving 167 240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings. Results. In the study 18 407 children (11.0%) developed asthma, with a median age at onset of 11 months. The relative risks (95% confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (NMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine. Conclusion. There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.

Original languageEnglish (US)
Pages (from-to)498-504
Number of pages7
JournalPediatric Infectious Disease Journal
Volume21
Issue number6
DOIs
StatePublished - Jun 24 2002

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Haemophilus influenzae type b
Vaccination
Asthma
Pertussis Vaccine
Hepatitis B Vaccines
Measles-Mumps-Rubella Vaccine
Diphtheria
Vaccines
Health Maintenance Organizations
Tetanus
Poliomyelitis
Patient Acceptance of Health Care
Age of Onset
Immunization
Cohort Studies
Parturition
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Destefano, F., Gu, D., Kramarz, P., Truman, B. I., Iademarco, M. F., Mullooly, J. P., ... Chen, R. T. (2002). Childhood vaccinations and risk of asthma. Pediatric Infectious Disease Journal, 21(6), 498-504. https://doi.org/10.1097/00006454-200206000-00004

Childhood vaccinations and risk of asthma. / Destefano, Frank; Gu, David; Kramarz, Piotr; Truman, Benedict I.; Iademarco, Michael F.; Mullooly, John P.; Jackson, Lisa A.; Davis, Robert; Black, Steven B.; Shinefield, Henry R.; Marcy, S. Michael; Ward, Joel I.; Chen, Robert T.

In: Pediatric Infectious Disease Journal, Vol. 21, No. 6, 24.06.2002, p. 498-504.

Research output: Contribution to journalArticle

Destefano, F, Gu, D, Kramarz, P, Truman, BI, Iademarco, MF, Mullooly, JP, Jackson, LA, Davis, R, Black, SB, Shinefield, HR, Marcy, SM, Ward, JI & Chen, RT 2002, 'Childhood vaccinations and risk of asthma', Pediatric Infectious Disease Journal, vol. 21, no. 6, pp. 498-504. https://doi.org/10.1097/00006454-200206000-00004
Destefano F, Gu D, Kramarz P, Truman BI, Iademarco MF, Mullooly JP et al. Childhood vaccinations and risk of asthma. Pediatric Infectious Disease Journal. 2002 Jun 24;21(6):498-504. https://doi.org/10.1097/00006454-200206000-00004
Destefano, Frank ; Gu, David ; Kramarz, Piotr ; Truman, Benedict I. ; Iademarco, Michael F. ; Mullooly, John P. ; Jackson, Lisa A. ; Davis, Robert ; Black, Steven B. ; Shinefield, Henry R. ; Marcy, S. Michael ; Ward, Joel I. ; Chen, Robert T. / Childhood vaccinations and risk of asthma. In: Pediatric Infectious Disease Journal. 2002 ; Vol. 21, No. 6. pp. 498-504.
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abstract = "Background. A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma. Methods. Cohort study involving 167 240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings. Results. In the study 18 407 children (11.0{\%}) developed asthma, with a median age at onset of 11 months. The relative risks (95{\%} confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (NMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine. Conclusion. There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.",
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