Chinese Time Trade-Off Values for EQ-5D Health States

Gordon G. Liu, Hongyan Wu, Minghui Li, Chen Gao, Nan Luo

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Objective To generate a Chinese general population-based three-level EuroQol five-dimensios (EQ-5D-3L) social value set using the time trade-off method. Methods The study sample was drawn from five cities in China: Beijing, Guangzhou, Shenyang, Chengdu, and Nanjing, using a quota sampling method. Utility values for a subset of 97 health states defined by the EQ-5D-3L descriptive system were directly elicited from the study sample using a modified Measurement and Valuation of Health protocol, with each respondent valuing 13 of the health states. The utility values for all 243 EQ-5D-3L health states were estimated on the basis of econometric models at both individual and aggregate levels. Various linear regression models using different model specifications were examined to determine the best model using predefined model selection criteria. Results The N3 model based on ordinary least square regression at the aggregate level yielded the best model fit, with a mean absolute error of 0.020, 7 and 0 states for which prediction errors were greater than 0.05 and 0.10, respectively, in absolute magnitude. This model passed tests for model misspecification (F = 2.7; P = 0.0509, Ramsey Regression Equation Specification Error Test), heteroskedasticity (χ2 = 0.97; P = 0.3254, Breusch-Pagan/Cook-Weisberg test), and normality of the residuals (χ2 = 1.285; P = 0.5259, Jarque-Bera test). The range of the predicted values (-0.149 to 0.887) was similar to those estimated in other countries. Conclusions The study successfully developed Chinese utility values for EQ-5D-3L health states using the time trade-off method. It is the first attempt ever to develop a standardized instrument for quantifying quality-adjusted life-years in China.

Original languageEnglish (US)
Pages (from-to)597-604
Number of pages8
JournalValue in Health
Volume17
Issue number5
DOIs
StatePublished - Jan 1 2014

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Health
Linear Models
China
Econometric Models
Social Values
Quality-Adjusted Life Years
Least-Squares Analysis
Patient Selection
Population
Surveys and Questionnaires
Beijing

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Chinese Time Trade-Off Values for EQ-5D Health States. / Liu, Gordon G.; Wu, Hongyan; Li, Minghui; Gao, Chen; Luo, Nan.

In: Value in Health, Vol. 17, No. 5, 01.01.2014, p. 597-604.

Research output: Contribution to journalArticle

Liu, Gordon G. ; Wu, Hongyan ; Li, Minghui ; Gao, Chen ; Luo, Nan. / Chinese Time Trade-Off Values for EQ-5D Health States. In: Value in Health. 2014 ; Vol. 17, No. 5. pp. 597-604.
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abstract = "Objective To generate a Chinese general population-based three-level EuroQol five-dimensios (EQ-5D-3L) social value set using the time trade-off method. Methods The study sample was drawn from five cities in China: Beijing, Guangzhou, Shenyang, Chengdu, and Nanjing, using a quota sampling method. Utility values for a subset of 97 health states defined by the EQ-5D-3L descriptive system were directly elicited from the study sample using a modified Measurement and Valuation of Health protocol, with each respondent valuing 13 of the health states. The utility values for all 243 EQ-5D-3L health states were estimated on the basis of econometric models at both individual and aggregate levels. Various linear regression models using different model specifications were examined to determine the best model using predefined model selection criteria. Results The N3 model based on ordinary least square regression at the aggregate level yielded the best model fit, with a mean absolute error of 0.020, 7 and 0 states for which prediction errors were greater than 0.05 and 0.10, respectively, in absolute magnitude. This model passed tests for model misspecification (F = 2.7; P = 0.0509, Ramsey Regression Equation Specification Error Test), heteroskedasticity (χ2 = 0.97; P = 0.3254, Breusch-Pagan/Cook-Weisberg test), and normality of the residuals (χ2 = 1.285; P = 0.5259, Jarque-Bera test). The range of the predicted values (-0.149 to 0.887) was similar to those estimated in other countries. Conclusions The study successfully developed Chinese utility values for EQ-5D-3L health states using the time trade-off method. It is the first attempt ever to develop a standardized instrument for quantifying quality-adjusted life-years in China.",
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