Chitosan films

A potential local drug delivery system for antibiotics

Scott P. Noel, Harry Courtney, Joel D. Bumgardner, Warren O. Haggard

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Local antibiotic delivery is an emerging area of study designed to provide alternative methods of treatment to clinicians for compromised wound sites where avascular zones can prevent the delivery of antibiotics to the infected tissue. Antibiotic-loaded bone cement is the gold standard for drug-eluting local delivery devices but is not ideal because it requires a removal surgery. Chitosan is a biocompatible, biodegradable polymer that has been used in several different drug delivery applications. We evaluated chitosan as a potential localized drug delivery device. We specifically determined if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting S. aureus growth. Elution of amikacin was 24.67 ± 2.35 μg/mL (85.68%) after 1 hour with a final cumulative release of 27.31 ± 2.86 μg/mL (96.23%) after 72 hours. Elution of daptomycin was 10.17 ± 3.83 μg/mL after 1 hour (31.61% release) and 28.72 ± 6.80 μg/mL after 72 hours (88.55%). The data from the elution study suggested effective release of amikacin and daptomycin. The activity studies indicated the eluants inhibited the growth of S. aureus. Incorporating antibiotics in chitosan could provide alternative methods of treating musculoskeletal infections.

Original languageEnglish (US)
Pages (from-to)1377-1382
Number of pages6
JournalClinical Orthopaedics and Related Research
Volume466
Issue number6
DOIs
StatePublished - Jan 1 2008

Fingerprint

Chitosan
Drug Delivery Systems
Anti-Bacterial Agents
Daptomycin
Amikacin
Pharmaceutical Preparations
Equipment and Supplies
Bone Cements
Growth
Polymers
Wounds and Injuries
Infection

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Chitosan films : A potential local drug delivery system for antibiotics. / Noel, Scott P.; Courtney, Harry; Bumgardner, Joel D.; Haggard, Warren O.

In: Clinical Orthopaedics and Related Research, Vol. 466, No. 6, 01.01.2008, p. 1377-1382.

Research output: Contribution to journalArticle

Noel, Scott P. ; Courtney, Harry ; Bumgardner, Joel D. ; Haggard, Warren O. / Chitosan films : A potential local drug delivery system for antibiotics. In: Clinical Orthopaedics and Related Research. 2008 ; Vol. 466, No. 6. pp. 1377-1382.
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