Cholinergic interneuron characteristics and nicotinic properties in the striatum

Fuming Zhou, Charles J. Wilson, John A. Dani

Research output: Contribution to journalArticle

279 Citations (Scopus)

Abstract

The neostriatum (dorsal striatum) is composed of the caudate and putamen. The ventral striatum is the ventral conjunction of the caudate and putamen that merges into and includes the nucleus accumbens and striatal portions of the olfactory tubercle. About 2% of the striatal neurons are cholinergic. Most cholinergic neurons in the central nervous system make diffuse projections that sparsely innervate relatively broad areas. In the striatum, however, the cholinergic neurons are interneurons that provide very dense local innervation. The cholinergic interneurons provide an ongoing acetylcholine (ACh) signal by firing action potentials tonically at about 5 Hz. A high concentration of acetylcholinesterase in the striatum rapidly terminates the ACh signal, and thereby minimizes desensitization of nicotinic acetylcholine receptors. Among the many muscarinic and nicotinic striatal mechanisms, the ongoing nicotinic activity potently enhances dopamine release. This process is among those in the striatum that link the two extensive and dense local arbors of the cholinergic interneurons and dopaminergic afferent fibers. During a conditioned motor task, cholinergic interneurons respond with a pause in their tonic firing. It is reasonable to hypothesize that this pause in the cholinergic activity alters action potential dependent dopamine release. The correlated response of these two broad and dense neurotransmitter systems helps to coordinate the output of the striatum, and is likely to be an important process in sensorimotor planning and learning.

Original languageEnglish (US)
Pages (from-to)590-605
Number of pages16
JournalJournal of Neurobiology
Volume53
Issue number4
DOIs
StatePublished - Dec 1 2002

Fingerprint

Interneurons
Cholinergic Agents
Corpus Striatum
Cholinergic Neurons
Putamen
Action Potentials
Acetylcholine
Dopamine
Neostriatum
Nucleus Accumbens
Nicotinic Receptors
Acetylcholinesterase
Neurotransmitter Agents
Central Nervous System
Learning

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Cholinergic interneuron characteristics and nicotinic properties in the striatum. / Zhou, Fuming; Wilson, Charles J.; Dani, John A.

In: Journal of Neurobiology, Vol. 53, No. 4, 01.12.2002, p. 590-605.

Research output: Contribution to journalArticle

Zhou, Fuming ; Wilson, Charles J. ; Dani, John A. / Cholinergic interneuron characteristics and nicotinic properties in the striatum. In: Journal of Neurobiology. 2002 ; Vol. 53, No. 4. pp. 590-605.
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