Cholinergic modulation during acquisition of olfactory fear conditioning alters learning and stimulus generalization in mice

Eloisa Pavesi, Allison Gooch, Elizabeth Lee, Max Fletcher

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We investigated the role of cholinergic neurotransmission in olfactory fear learning. Mice receiving pairings of odor and foot shock displayed fear to the trained odor the following day. Pretraining injections of the nicotinic antagonist mecamylamine had no effect on subsequent freezing, while the muscarinic antagonist scopolamine significantly reduced freezing. To test whether cholinergic manipulation affected fear generalization, mice were presented with odors similar to the trained odor. Generalization was increased following pretraining scopolamine, while the muscarinic agonist oxotremorine decreased generalization. These results suggest that muscarinic neurotransmission during the acquisition of olfactory association modulates both the strength and specificity of learning.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalLearning and Memory
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2013

Fingerprint

Stimulus Generalization
Cholinergic Agents
Fear
Learning
Scopolamine Hydrobromide
Synaptic Transmission
Freezing
Nicotinic Antagonists
Oxotremorine
Mecamylamine
Muscarinic Agonists
Muscarinic Antagonists
Foot
Shock
Injections
Odorants
Conditioning (Psychology)
Generalization (Psychology)

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Cholinergic modulation during acquisition of olfactory fear conditioning alters learning and stimulus generalization in mice. / Pavesi, Eloisa; Gooch, Allison; Lee, Elizabeth; Fletcher, Max.

In: Learning and Memory, Vol. 20, No. 1, 01.01.2013, p. 6-10.

Research output: Contribution to journalArticle

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