Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study tested the hypothesis that cholinoceptive regions of the medial pontine reticular formation (mPRF), long known to play a role in regulating the sleep cycle, can also causally alter the respiratory cycle. In 4 cats, sleep and wakefulness were polygraphically recorded while simultaneous measures were taken of rate of breathing, tidal volume, minute ventilation, respiratory cycle timing, and end-tidal CO2 concentration. Respiration during naturally occurring rapid eye movement (REM) sleep was compared to breathing during wakefulness and during the REM sleep-like state (D Carb) caused by mPRF microinjections of the cholinergic agonist carbachol. The results demonstrate for the first time that non-respiratory regions of the cholinoceptive mPRF can cause statistically significant state-dependent alterations in respiration.

Original languageEnglish (US)
Pages (from-to)211-216
Number of pages6
JournalNeuroscience Letters
Volume102
Issue number2-3
DOIs
StatePublished - Jul 31 1989

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Sleep
Respiration
Cats
Wakefulness
REM Sleep
Cholinergic Agonists
Tidal Volume
Microinjections
Carbachol
Ventilation
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat. / Lydic, Ralph; Baghdoyan, Helen.

In: Neuroscience Letters, Vol. 102, No. 2-3, 31.07.1989, p. 211-216.

Research output: Contribution to journalArticle

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