Chromenes

Potential new chemotherapeutic agents for cancer

Shivaputra A. Patil, Renukadevi Patil, Lawrence Pfeffer, Duane Miller

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Cancer is a major devastating disease, and is a leading cause of death worldwide. Despite the progress in cancer treatment, cancer mortality rate remains high. Therefore, the discovery and development of improved anticancer drugs to treat cancer are needed. 4H-chromenes have strong cytotoxicity against a panel of human cancer cell lines involving pathways that include microtubule depolarization and tumor vasculature disruption. A chromene analog, Crolibulin™ (EPC2407) is currently in Phase I/II clinical trials for the treatment of advanced solid tumors. This article reviews the general synthesis, biological activities and structure-activity relatinships of different classes of chromenes.

Original languageEnglish (US)
Pages (from-to)1647-1660
Number of pages14
JournalFuture Medicinal Chemistry
Volume5
Issue number14
DOIs
StatePublished - Sep 1 2013

Fingerprint

Benzopyrans
Neoplasms
Phase II Clinical Trials
Clinical Trials, Phase I
Microtubules
Cause of Death
Cell Line
Mortality
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

Cite this

Chromenes : Potential new chemotherapeutic agents for cancer. / Patil, Shivaputra A.; Patil, Renukadevi; Pfeffer, Lawrence; Miller, Duane.

In: Future Medicinal Chemistry, Vol. 5, No. 14, 01.09.2013, p. 1647-1660.

Research output: Contribution to journalReview article

Patil, Shivaputra A. ; Patil, Renukadevi ; Pfeffer, Lawrence ; Miller, Duane. / Chromenes : Potential new chemotherapeutic agents for cancer. In: Future Medicinal Chemistry. 2013 ; Vol. 5, No. 14. pp. 1647-1660.
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