Chromosomal regions harboring genes for the work to femur failure in mice

Xinmin Li, Godfred Masinde, Weikuan Gu, Jon Wergedal, Melanie Hamilton-Ulland, Shizhong Xu, Subburaman Mohan, David J. Baylink

Research output: Contribution to journalArticle

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Abstract

The work to failure is defined as the maximum energy bone can absorb before breaking, and therefore is a direct test of the risk of fracture. To determine the genetic loci influencing work to failure, we have performed a high density genome-wide scan in 633 (MRL× SJL) F2 female mice. Five loci (P < 0.005) with significant effects on work to failure were found on chromosomes 2, 7, 8, 9, and X, which collectively explained around 20% variance of work to femur failure in F2 mice. Of those, only the QTL on chromosome 9 was concordant with bone mineral density (BMD) QTLs. Eight significant interactions (P < 0.01) between marker loci were identified, which accounted for an equivalent amount of F2 variance (23%) to combined single QTL effects. Our results demonstrate that most of the genetic loci regulating work to failure are different from those for BMD in the 7-week-old female mice. If this is also true in humans, this finding will challenge the predictive value of BMD for the risk of fracture.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalFunctional and Integrative Genomics
Volume1
Issue number6
DOIs
StatePublished - Apr 1 2002

Fingerprint

Femur
Bone Density
Genetic Loci
Genes
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 2
Genome
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Li, X., Masinde, G., Gu, W., Wergedal, J., Hamilton-Ulland, M., Xu, S., ... Baylink, D. J. (2002). Chromosomal regions harboring genes for the work to femur failure in mice. Functional and Integrative Genomics, 1(6), 367-374. https://doi.org/10.1007/s10142-001-0045-z

Chromosomal regions harboring genes for the work to femur failure in mice. / Li, Xinmin; Masinde, Godfred; Gu, Weikuan; Wergedal, Jon; Hamilton-Ulland, Melanie; Xu, Shizhong; Mohan, Subburaman; Baylink, David J.

In: Functional and Integrative Genomics, Vol. 1, No. 6, 01.04.2002, p. 367-374.

Research output: Contribution to journalArticle

Li, X, Masinde, G, Gu, W, Wergedal, J, Hamilton-Ulland, M, Xu, S, Mohan, S & Baylink, DJ 2002, 'Chromosomal regions harboring genes for the work to femur failure in mice', Functional and Integrative Genomics, vol. 1, no. 6, pp. 367-374. https://doi.org/10.1007/s10142-001-0045-z
Li, Xinmin ; Masinde, Godfred ; Gu, Weikuan ; Wergedal, Jon ; Hamilton-Ulland, Melanie ; Xu, Shizhong ; Mohan, Subburaman ; Baylink, David J. / Chromosomal regions harboring genes for the work to femur failure in mice. In: Functional and Integrative Genomics. 2002 ; Vol. 1, No. 6. pp. 367-374.
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