Chromosome aberrations in four ependymomas

Jeffrey R. Sawyer, Gael Sammartino, M. Husain, Frederick Boop, William M. Chadduck

Research output: Contribution to journalArticle

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Abstract

Cytogenetic analysis of short-term cultures from three untreated and one recurrent ependymoma revealed clonal aberrations in three of the four tumors. A posterior fossa ependymoma from a 3-year-old male patient showed trisomy 11 as the sole clonal chromosome aberration. A recurrent spinal ependymoma from a 35-year-old male showed hypertriploid clones with abnormalities involving chromosomes 1p11,7q21, and 10p13. A 62-year-old male patient with a cerebellar ependymoma showed a hypodiploid stem-cell line with clonal structural aberrations of both the long and short arms of chromosome 1, an interstitial deletion of 2q, trisomy 7, and monosomy for chromosomes 11, 13, and 16. A 3-year-old female patient with posterior fossa ependymoma showed a normal 46,XX karyotype. Chromosome 1 aberrations appear to be the most consistent finding in this small series of tumors, with the net loss or rearrangement of chromosome 1 pter→p22 material from two of the four tumors. These findings, in addition to a previously published case [1], suggest a possible role for genes on the short arm of chromosome 1 in the cytogenetic evaluation of ependymomas.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume74
Issue number2
DOIs
StatePublished - Jan 1 1994

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Ependymoma
Chromosome Aberrations
Chromosomes, Human, Pair 1
Trisomy
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 13
Neoplasms
Chromosomes, Human, Pair 11
Cytogenetic Analysis
Karyotype
Cytogenetics
Stem Cells
Clone Cells
Cell Line
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Sawyer, J. R., Sammartino, G., Husain, M., Boop, F., & Chadduck, W. M. (1994). Chromosome aberrations in four ependymomas. Cancer Genetics and Cytogenetics, 74(2), 132-138. https://doi.org/10.1016/0165-4608(94)90011-6

Chromosome aberrations in four ependymomas. / Sawyer, Jeffrey R.; Sammartino, Gael; Husain, M.; Boop, Frederick; Chadduck, William M.

In: Cancer Genetics and Cytogenetics, Vol. 74, No. 2, 01.01.1994, p. 132-138.

Research output: Contribution to journalArticle

Sawyer, JR, Sammartino, G, Husain, M, Boop, F & Chadduck, WM 1994, 'Chromosome aberrations in four ependymomas', Cancer Genetics and Cytogenetics, vol. 74, no. 2, pp. 132-138. https://doi.org/10.1016/0165-4608(94)90011-6
Sawyer, Jeffrey R. ; Sammartino, Gael ; Husain, M. ; Boop, Frederick ; Chadduck, William M. / Chromosome aberrations in four ependymomas. In: Cancer Genetics and Cytogenetics. 1994 ; Vol. 74, No. 2. pp. 132-138.
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