Chronic hypersensitivity lung disease with recurrent episodes of hypersensitivity pneumonitis due to a contaminated central humidifier

Michael Miller, ROY PATTERSON, JORDAN N. FINK, MARY ROBERTS

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A child with a 4‐year history of acute and chronic respiratory symptoms of unknown aetiology was investigated for hypersensitivity pneumonitis. Lung disease due to inhalation of material from a contaminated central humidifier was suggested by the clinical history, the presence of precipitating antibodies in the serum against the humidifier water, a pulmonary response to challenge with the humidifier water, and marked improvement after removal of the humidifier. No fungi were cultured from the humidifier nor were antibodies against a number of fungal antigens identified by radioimmunoassay inhibition techniques. Antigenic material was found in the humidifier water and the household water prior to its reaching the humidifier. This antigenic material was not found in laboratory tap water supplied from the same general source (Lake Michigan) but from a different pumping station. Three of the child's siblings gave histories suggestive of a single concurrent episode of acute hypersensitivity pneumonitis and one sibling had a history suggestive of chronic hypersensitivity lung disease. No association could be found between HLA‐haplotypy and disease in the patient and the siblings.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalClinical & Experimental Allergy
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

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Extrinsic Allergic Alveolitis
Lung Diseases
Hypersensitivity
Water
Siblings
Fungal Antigens
Antibodies
Lakes
Humidifiers
Inhalation
Radioimmunoassay
Fungi
History
Lung
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Chronic hypersensitivity lung disease with recurrent episodes of hypersensitivity pneumonitis due to a contaminated central humidifier. / Miller, Michael; PATTERSON, ROY; FINK, JORDAN N.; ROBERTS, MARY.

In: Clinical & Experimental Allergy, Vol. 6, No. 5, 01.01.1976, p. 451-462.

Research output: Contribution to journalArticle

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