Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression

Joel Gradowski, Rachel L. Sargent, Fiona E. Craig, Kathleen Cieply, Kim Fuhrer, Carol Sherer, Steven H. Swerdlow

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cyclin D1 expression, usually absent in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has been described in the proliferation centers (PC) of some CLL/SLL. The prevalence of this finding is uncertain, as is the explanation for its occurrence and whether these cases have any other unique features. Cyclin D1 immunohistochemical staining was therefore investigated in 57 extramedullary CLL/SLL biopsies. In 6 cases, cyclin D1 immunofluorescence followed by CCND1 fluorescence in situ hybridization (FISH) and PC targeted analysis was performed using a Bioview Duet system. Excluding the prospectively selected cases that had the targeted FISH studies, cyclin D1+ PC were identified in 20% of cases. The cyclin D1+ CLL did not appear pathologically or phenotypically distinctive, though 46% had an interfollicular growth pattern. The cyclin D1+ PCs were SOX11- and lacked CCND1 translocations and gains in 5 of 5 informative cases. The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume138
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

Fingerprint

Cyclin D1
B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Mantle-Cell Lymphoma
Fluorescent Antibody Technique
Staining and Labeling
Biopsy
Growth

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression. / Gradowski, Joel; Sargent, Rachel L.; Craig, Fiona E.; Cieply, Kathleen; Fuhrer, Kim; Sherer, Carol; Swerdlow, Steven H.

In: American Journal of Clinical Pathology, Vol. 138, No. 1, 01.07.2012, p. 132-139.

Research output: Contribution to journalArticle

Gradowski, Joel ; Sargent, Rachel L. ; Craig, Fiona E. ; Cieply, Kathleen ; Fuhrer, Kim ; Sherer, Carol ; Swerdlow, Steven H. / Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression. In: American Journal of Clinical Pathology. 2012 ; Vol. 138, No. 1. pp. 132-139.
@article{47c75d8cbe314b15a8eb309113c1a6ae,
title = "Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression",
abstract = "Cyclin D1 expression, usually absent in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has been described in the proliferation centers (PC) of some CLL/SLL. The prevalence of this finding is uncertain, as is the explanation for its occurrence and whether these cases have any other unique features. Cyclin D1 immunohistochemical staining was therefore investigated in 57 extramedullary CLL/SLL biopsies. In 6 cases, cyclin D1 immunofluorescence followed by CCND1 fluorescence in situ hybridization (FISH) and PC targeted analysis was performed using a Bioview Duet system. Excluding the prospectively selected cases that had the targeted FISH studies, cyclin D1+ PC were identified in 20{\%} of cases. The cyclin D1+ CLL did not appear pathologically or phenotypically distinctive, though 46{\%} had an interfollicular growth pattern. The cyclin D1+ PCs were SOX11- and lacked CCND1 translocations and gains in 5 of 5 informative cases. The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma.",
author = "Joel Gradowski and Sargent, {Rachel L.} and Craig, {Fiona E.} and Kathleen Cieply and Kim Fuhrer and Carol Sherer and Swerdlow, {Steven H.}",
year = "2012",
month = "7",
day = "1",
doi = "10.1309/AJCPIVKZRMPF93ET",
language = "English (US)",
volume = "138",
pages = "132--139",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

TY - JOUR

T1 - Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression

AU - Gradowski, Joel

AU - Sargent, Rachel L.

AU - Craig, Fiona E.

AU - Cieply, Kathleen

AU - Fuhrer, Kim

AU - Sherer, Carol

AU - Swerdlow, Steven H.

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Cyclin D1 expression, usually absent in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has been described in the proliferation centers (PC) of some CLL/SLL. The prevalence of this finding is uncertain, as is the explanation for its occurrence and whether these cases have any other unique features. Cyclin D1 immunohistochemical staining was therefore investigated in 57 extramedullary CLL/SLL biopsies. In 6 cases, cyclin D1 immunofluorescence followed by CCND1 fluorescence in situ hybridization (FISH) and PC targeted analysis was performed using a Bioview Duet system. Excluding the prospectively selected cases that had the targeted FISH studies, cyclin D1+ PC were identified in 20% of cases. The cyclin D1+ CLL did not appear pathologically or phenotypically distinctive, though 46% had an interfollicular growth pattern. The cyclin D1+ PCs were SOX11- and lacked CCND1 translocations and gains in 5 of 5 informative cases. The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma.

AB - Cyclin D1 expression, usually absent in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), has been described in the proliferation centers (PC) of some CLL/SLL. The prevalence of this finding is uncertain, as is the explanation for its occurrence and whether these cases have any other unique features. Cyclin D1 immunohistochemical staining was therefore investigated in 57 extramedullary CLL/SLL biopsies. In 6 cases, cyclin D1 immunofluorescence followed by CCND1 fluorescence in situ hybridization (FISH) and PC targeted analysis was performed using a Bioview Duet system. Excluding the prospectively selected cases that had the targeted FISH studies, cyclin D1+ PC were identified in 20% of cases. The cyclin D1+ CLL did not appear pathologically or phenotypically distinctive, though 46% had an interfollicular growth pattern. The cyclin D1+ PCs were SOX11- and lacked CCND1 translocations and gains in 5 of 5 informative cases. The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma.

UR - http://www.scopus.com/inward/record.url?scp=84864225880&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864225880&partnerID=8YFLogxK

U2 - 10.1309/AJCPIVKZRMPF93ET

DO - 10.1309/AJCPIVKZRMPF93ET

M3 - Article

C2 - 22706868

AN - SCOPUS:84864225880

VL - 138

SP - 132

EP - 139

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 1

ER -