Chronic mineralocorticoid excess and cardiovascular remodeling

Karl Weber, Yao Sun, Scott E. Campbell, Simon H. Slight, Venkataseshu K. Ganjam, George T. Griffing, Ronald W. Swinfard, Alberto A. Diaz-Arias

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Chronic mineralocorticoid (MC) excess, whether due to elevated plasma aldosterone (ALDO) or deoxycorticosterone (DOC), is associated with a perivascular fibrosis of systemic and coronary arterioles. This remodeling of resistance vessels contributes to the appearance of hypertension. Chronic MC excess is also accompanied by cardiac myocyte necrosis, secondary to myocardial potassium depletion, and a subsequent reparative fibrosis that appears in the normotensive, nonhypertrophied right and hypertensive, hypertrophied left ventricles. Fibrosis contributes to the appearance of ventricular arrhythmias and dysfunction. Herein, clinical and experimental evidence linking chronic, inappropriate (relative to dietary sodium) elevations in circulating ALDO and DOC with these reactive and reparative forms of fibrous tissue formation in the heart and other tissues is presented.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalSteroids
Volume60
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

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Desoxycorticosterone
Mineralocorticoids
Aldosterone
Fibrosis
Tissue
Dietary Sodium
Ventricular Dysfunction
Potassium
Sodium
Arterioles
Plasmas
Cardiac Myocytes
Heart Ventricles
Cardiac Arrhythmias
Necrosis
Hypertension

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Weber, K., Sun, Y., Campbell, S. E., Slight, S. H., Ganjam, V. K., Griffing, G. T., ... Diaz-Arias, A. A. (1995). Chronic mineralocorticoid excess and cardiovascular remodeling. Steroids, 60(1), 125-132. https://doi.org/10.1016/0039-128X(94)00030-G

Chronic mineralocorticoid excess and cardiovascular remodeling. / Weber, Karl; Sun, Yao; Campbell, Scott E.; Slight, Simon H.; Ganjam, Venkataseshu K.; Griffing, George T.; Swinfard, Ronald W.; Diaz-Arias, Alberto A.

In: Steroids, Vol. 60, No. 1, 01.01.1995, p. 125-132.

Research output: Contribution to journalArticle

Weber, K, Sun, Y, Campbell, SE, Slight, SH, Ganjam, VK, Griffing, GT, Swinfard, RW & Diaz-Arias, AA 1995, 'Chronic mineralocorticoid excess and cardiovascular remodeling', Steroids, vol. 60, no. 1, pp. 125-132. https://doi.org/10.1016/0039-128X(94)00030-G
Weber K, Sun Y, Campbell SE, Slight SH, Ganjam VK, Griffing GT et al. Chronic mineralocorticoid excess and cardiovascular remodeling. Steroids. 1995 Jan 1;60(1):125-132. https://doi.org/10.1016/0039-128X(94)00030-G
Weber, Karl ; Sun, Yao ; Campbell, Scott E. ; Slight, Simon H. ; Ganjam, Venkataseshu K. ; Griffing, George T. ; Swinfard, Ronald W. ; Diaz-Arias, Alberto A. / Chronic mineralocorticoid excess and cardiovascular remodeling. In: Steroids. 1995 ; Vol. 60, No. 1. pp. 125-132.
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