Chronic opiate use in pregnancy and newborn head circumference

Kevin C. Visconti, Kerry C. Hennessy, Craig V. Towers, Bobby C. Howard

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVE: The aim of the study is to evaluate whether chronic opiate use in pregnancy affects newborn head circumference (HC).

STUDY DESIGN: All newborns from January 1, 2010, to June 30, 2012, admitted to the neonatal intensive care unit for treatment of neonatal abstinence syndrome were prospectively collected. The demographic, obstetrical, neonatal, and perinatal ultrasound data were retrospectively obtained. A gestational age-matched control was used for comparison purposes.

RESULTS: Of 332 neonates admitted for the treatment of neonatal abstinence syndrome, 98 (29.5%) had a HC ≤ 10th percentile for gestational age that was significantly increased when compared with controls (p < 0.001). Of these 98, 25 had a HC ≤ 3rd percentile. Of the case population, 141 had an ultrasound in the perinatal unit within 10 days of birth. A HC < 5th percentile was found in 38.3% of cases of which 74% were ≤ 10th percentile postdelivery. The ultrasound femur and humerus length measurements were also < 5th percentile in 36.2 and 28.9%, respectively.

CONCLUSION: Chronic opiate use in pregnancy appears to increase the risk for a HC ≤ 10th percentile and ≤ 3rd percentile when compared with controls. From ultrasound findings, femur and humerus lengths also appear to be shortened suggesting a possible effect on bone growth.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalAmerican Journal of Perinatology
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Opiate Alkaloids
Neonatal Abstinence Syndrome
Humerus
Femur
Gestational Age
Head
Pregnancy
Neonatal Intensive Care Units
Bone Development
Demography
Parturition
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Chronic opiate use in pregnancy and newborn head circumference. / Visconti, Kevin C.; Hennessy, Kerry C.; Towers, Craig V.; Howard, Bobby C.

In: American Journal of Perinatology, Vol. 32, No. 1, 01.01.2015, p. 27-32.

Research output: Contribution to journalArticle

@article{a706a51723ff43ac9795eb4d66ece816,
title = "Chronic opiate use in pregnancy and newborn head circumference",
abstract = "OBJECTIVE: The aim of the study is to evaluate whether chronic opiate use in pregnancy affects newborn head circumference (HC).STUDY DESIGN: All newborns from January 1, 2010, to June 30, 2012, admitted to the neonatal intensive care unit for treatment of neonatal abstinence syndrome were prospectively collected. The demographic, obstetrical, neonatal, and perinatal ultrasound data were retrospectively obtained. A gestational age-matched control was used for comparison purposes.RESULTS: Of 332 neonates admitted for the treatment of neonatal abstinence syndrome, 98 (29.5{\%}) had a HC ≤ 10th percentile for gestational age that was significantly increased when compared with controls (p < 0.001). Of these 98, 25 had a HC ≤ 3rd percentile. Of the case population, 141 had an ultrasound in the perinatal unit within 10 days of birth. A HC < 5th percentile was found in 38.3{\%} of cases of which 74{\%} were ≤ 10th percentile postdelivery. The ultrasound femur and humerus length measurements were also < 5th percentile in 36.2 and 28.9{\%}, respectively.CONCLUSION: Chronic opiate use in pregnancy appears to increase the risk for a HC ≤ 10th percentile and ≤ 3rd percentile when compared with controls. From ultrasound findings, femur and humerus lengths also appear to be shortened suggesting a possible effect on bone growth.",
author = "Visconti, {Kevin C.} and Hennessy, {Kerry C.} and Towers, {Craig V.} and Howard, {Bobby C.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1055/s-0034-1374817",
language = "English (US)",
volume = "32",
pages = "27--32",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "1",

}

TY - JOUR

T1 - Chronic opiate use in pregnancy and newborn head circumference

AU - Visconti, Kevin C.

AU - Hennessy, Kerry C.

AU - Towers, Craig V.

AU - Howard, Bobby C.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - OBJECTIVE: The aim of the study is to evaluate whether chronic opiate use in pregnancy affects newborn head circumference (HC).STUDY DESIGN: All newborns from January 1, 2010, to June 30, 2012, admitted to the neonatal intensive care unit for treatment of neonatal abstinence syndrome were prospectively collected. The demographic, obstetrical, neonatal, and perinatal ultrasound data were retrospectively obtained. A gestational age-matched control was used for comparison purposes.RESULTS: Of 332 neonates admitted for the treatment of neonatal abstinence syndrome, 98 (29.5%) had a HC ≤ 10th percentile for gestational age that was significantly increased when compared with controls (p < 0.001). Of these 98, 25 had a HC ≤ 3rd percentile. Of the case population, 141 had an ultrasound in the perinatal unit within 10 days of birth. A HC < 5th percentile was found in 38.3% of cases of which 74% were ≤ 10th percentile postdelivery. The ultrasound femur and humerus length measurements were also < 5th percentile in 36.2 and 28.9%, respectively.CONCLUSION: Chronic opiate use in pregnancy appears to increase the risk for a HC ≤ 10th percentile and ≤ 3rd percentile when compared with controls. From ultrasound findings, femur and humerus lengths also appear to be shortened suggesting a possible effect on bone growth.

AB - OBJECTIVE: The aim of the study is to evaluate whether chronic opiate use in pregnancy affects newborn head circumference (HC).STUDY DESIGN: All newborns from January 1, 2010, to June 30, 2012, admitted to the neonatal intensive care unit for treatment of neonatal abstinence syndrome were prospectively collected. The demographic, obstetrical, neonatal, and perinatal ultrasound data were retrospectively obtained. A gestational age-matched control was used for comparison purposes.RESULTS: Of 332 neonates admitted for the treatment of neonatal abstinence syndrome, 98 (29.5%) had a HC ≤ 10th percentile for gestational age that was significantly increased when compared with controls (p < 0.001). Of these 98, 25 had a HC ≤ 3rd percentile. Of the case population, 141 had an ultrasound in the perinatal unit within 10 days of birth. A HC < 5th percentile was found in 38.3% of cases of which 74% were ≤ 10th percentile postdelivery. The ultrasound femur and humerus length measurements were also < 5th percentile in 36.2 and 28.9%, respectively.CONCLUSION: Chronic opiate use in pregnancy appears to increase the risk for a HC ≤ 10th percentile and ≤ 3rd percentile when compared with controls. From ultrasound findings, femur and humerus lengths also appear to be shortened suggesting a possible effect on bone growth.

UR - http://www.scopus.com/inward/record.url?scp=84941141705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941141705&partnerID=8YFLogxK

U2 - 10.1055/s-0034-1374817

DO - 10.1055/s-0034-1374817

M3 - Article

VL - 32

SP - 27

EP - 32

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 1

ER -