Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study

Paul Terry, A. B. Miller, J. G. Jones, T. E. Rohan

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Few cohort studies have examined the association between cigarette smoking and ovarian cancer risk, either overall, or by histological subtype. In relation to the latter, it has been suggested that mucinous ovarian tumours may be aetiologically unrelated to the other types of epithelial tumours and that their respective associations with cigarette smoking may differ. We examined the association between smoking and ovarian cancer risk using data from participants in a randomised controlled trial of screening for breast cancer involving 89,835 women aged 40-59 years at recruitment. Cox proportional hazards models were used to estimate rate ratios (RR) and 95% confidence intervals (CI). During an average of 16.5 years of follow-up, we observed 454 incident cases of ovarian cancer (184 serous, 67 endometrioid, 32 mucinous, 171 other or unknown). We found that women who had smoked for several decades had an approximately two-fold increased risk of epithelial ovarian cancer. Relative to never-smokers, women who had smoked for 40 years or more were at the highest risk (RR=2.50, 95% CI=1.37-4.56). The association with non-mucinous tumours was similar to that observed overall. For mucinous tumours, a two-fold increased risk was observed with smoking of shorter duration, although the number of mucinous tumours in our data-set was small. Long-term cigarette smoking may be associated with an increased risk of epithelial ovarian tumours.

Original languageEnglish (US)
Pages (from-to)1157-1164
Number of pages8
JournalEuropean Journal of Cancer
Volume39
Issue number8
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Cohort Studies
Smoking
Prospective Studies
Ovarian Neoplasms
Neoplasms
Confidence Intervals
Proportional Hazards Models
Ovarian epithelial cancer
Randomized Controlled Trials
Odds Ratio
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study. / Terry, Paul; Miller, A. B.; Jones, J. G.; Rohan, T. E.

In: European Journal of Cancer, Vol. 39, No. 8, 01.01.2003, p. 1157-1164.

Research output: Contribution to journalArticle

Terry, Paul ; Miller, A. B. ; Jones, J. G. ; Rohan, T. E. / Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study. In: European Journal of Cancer. 2003 ; Vol. 39, No. 8. pp. 1157-1164.
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