Cimetidine Does Not Inhibit Indomethacin-Induced Small Bowel Ulceration in the Rat

Gordon L. Kauffman, Kevin Foley, Morton I. Grossman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In earlier studies, cimetidine was found to protect against acetylsalicylic acid-induced gastric mucosal lesions by a mechanism other than inhibition of gastric acid secretion. The present study examined the possibility that cimetidine might protect against the intestinal mucosal injury produced by indomethacin. Small intestinal ulceration produced by oral indomethacin (20 mg kg-1) was studied in rats treated with 0.15 M NaCl (control); 80 mg kg-1 cimetidine; 400 mg kg -1 cimetidine; and 100 μug kg-1 16-16 dimethyl prostaglandin E2. The treatments were given 30 min before and 8 hr after indomethacin. Confirming previous studies, 16-16 DMPGE2 significantly (P < 0.01) reduced the number of lesions and the sum of the lengths of ulcers per rat when compared to the control group. Neither dose of cimetidine had any effect on the intestinal lesions.

Original languageEnglish (US)
Pages (from-to)512-514
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume161
Issue number4
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

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Cimetidine
Indomethacin
Rats
Gastric Acid
Dinoprostone
Aspirin
Ulcer
Stomach
Control Groups
Acids
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cimetidine Does Not Inhibit Indomethacin-Induced Small Bowel Ulceration in the Rat. / Kauffman, Gordon L.; Foley, Kevin; Grossman, Morton I.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 161, No. 4, 01.01.1979, p. 512-514.

Research output: Contribution to journalArticle

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