Cimetidine in the treatment of acute intermittent porphyria

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Treatment options for AIP remain limited. Although no single therapy has been proven superior in clinical trials, intravenous hemin appears to be more effective than increased carbohydrate intake, and remains the treatment of choice. At usual dosages the average wholesale price of heroin is $120-475 per day (for a patient weighing 70 kg), compared with $2.50 per day for cimetidine. Cimetidine may offer a more cost-effective and easily administered alternative to hemin therapy. The optimal dosage and duration of treatment with cimetidine have not been established and are likely to be patient-specific. Oral doses of 800 mg/d have been used. In addition to its potential for treatment, cimetidine may also have a role in prophylaxis of acute episodes by maintaining a baseline suppression of ALA synthase activity. Until well-designed, controlled clinical trials demonstrate its efficacy and compare it with other treatment options, cimetidine should be reserved for use only after standard treatment modalities have failed.

Original languageEnglish (US)
Pages (from-to)365-367
Number of pages3
JournalAnnals of Pharmacotherapy
Volume31
Issue number3
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Acute Intermittent Porphyria
Cimetidine
Hemin
Therapeutics
Heroin
Controlled Clinical Trials
Carbohydrates
Clinical Trials
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Cimetidine in the treatment of acute intermittent porphyria. / Rogers, Phillip.

In: Annals of Pharmacotherapy, Vol. 31, No. 3, 01.01.1997, p. 365-367.

Research output: Contribution to journalArticle

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