Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients

A 4-year prospective case-cohort study

Miklos Z. Molnar, Philipp Kümpers, Jan T. Kielstein, Mario Schiffer, Maria E. Czira, Akos Ujszaszi, Csaba Kovesdy, Istvan Mucsi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Angiopoietin 2 (Angpt2) impairs endothelial function by preventing angiopoietin 1 from binding to their common endothelial-specific receptor Tie2. Here, we examined whether circulating Angpt2 predicts outcome in kidney transplant recipients. For this case-cohort study, we selected 130 kidney transplant recipients who had died or returned to dialysis within the first 2 years of follow-up of our cohort study, as well as 130 age- and gender-matched kidney transplant recipients without an event (controls) from a total of 993 kidney transplant recipients. The total of 260 selected patients were followed in median 4 years. Serum Angpt2 at baseline was measured using an in-house immunoluminometric assay. Median Angpt2 concentrations were significantly higher in patients who died [median (interquartile range - IQR) 3.6 (2.8-5.9) ng/ml] as compared to patients who did not die during the study period [2.8 (2.1-4.1) ng/ml; P < 0.001]. Ln (natural log) Angpt2 levels correlated positively with C-reactive protein levels (r = 0.315, P < 0.001) and the Charlson Comorbidity Index (r = 0.188, P = 0.002) and were inversely associated with eGFR (r = -0.301, P < 0.001) hemoglobin (r = -0.269, P < 0.001), and serum albumin concentrations (r = -0.382, P < 0.001). On multivariate analyses, baseline Angpt2 levels independently predicted all-cause mortality (multivariable- adjusted hazard ratio associated with one natural log unit higher Angpt2 level: 1.70 (95% confidence interval: 1.10-2.61)). In our analysis, circulating Angpt2 was an independent predictor of all-cause mortality in stable, prevalent kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)541-552
Number of pages12
JournalTransplant International
Volume27
Issue number6
DOIs
StatePublished - Jan 1 2014

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Angiopoietin-2
Cohort Studies
Kidney
Mortality
TIE-2 Receptor
Angiopoietin-1
Transplant Recipients
Serum Albumin
C-Reactive Protein
Comorbidity
Dialysis
Hemoglobins
Multivariate Analysis
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Molnar, M. Z., Kümpers, P., Kielstein, J. T., Schiffer, M., Czira, M. E., Ujszaszi, A., ... Mucsi, I. (2014). Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients: A 4-year prospective case-cohort study. Transplant International, 27(6), 541-552. https://doi.org/10.1111/tri.12293

Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients : A 4-year prospective case-cohort study. / Molnar, Miklos Z.; Kümpers, Philipp; Kielstein, Jan T.; Schiffer, Mario; Czira, Maria E.; Ujszaszi, Akos; Kovesdy, Csaba; Mucsi, Istvan.

In: Transplant International, Vol. 27, No. 6, 01.01.2014, p. 541-552.

Research output: Contribution to journalArticle

Molnar, MZ, Kümpers, P, Kielstein, JT, Schiffer, M, Czira, ME, Ujszaszi, A, Kovesdy, C & Mucsi, I 2014, 'Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients: A 4-year prospective case-cohort study', Transplant International, vol. 27, no. 6, pp. 541-552. https://doi.org/10.1111/tri.12293
Molnar, Miklos Z. ; Kümpers, Philipp ; Kielstein, Jan T. ; Schiffer, Mario ; Czira, Maria E. ; Ujszaszi, Akos ; Kovesdy, Csaba ; Mucsi, Istvan. / Circulating Angiopoietin-2 levels predict mortality in kidney transplant recipients : A 4-year prospective case-cohort study. In: Transplant International. 2014 ; Vol. 27, No. 6. pp. 541-552.
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