Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction

Akihiko Taguchi, Nami Nakagomi, Tomohiro Matsuyama, Akie Kikuchi-Taura, Hiroo Yoshikawa, Yukiko Kasahara, Haruka Hirose, Hiroshi Moriwaki, Takayuki Nakagomi, Toshihiro Soma, David Stern, Hiroaki Naritomi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Increasing evidence points to a role for circulating endothelial progenitors, including populations of CD34-positive (CD34+) cells present in peripheral blood, in vascular homeostasis and neovascularization. In this report, circulating CD34+ cells in individuals with a history of cerebral infarction were correlated with changes in neurologic function over a period of 1 year. Patients with decreased levels of CD34+ cells displayed significant worsening in neurologic function, evaluated by the Barthel Index and Clinical Dementia Rating. These results support the hypothesis that levels of circulating CD34+ cells have prognostic value for neural function, consistent with their potential role in maintaining cerebral circulation.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

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Cerebral Infarction
Nervous System
Cerebrovascular Circulation
Blood Vessels
Dementia
Homeostasis
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction. / Taguchi, Akihiko; Nakagomi, Nami; Matsuyama, Tomohiro; Kikuchi-Taura, Akie; Yoshikawa, Hiroo; Kasahara, Yukiko; Hirose, Haruka; Moriwaki, Hiroshi; Nakagomi, Takayuki; Soma, Toshihiro; Stern, David; Naritomi, Hiroaki.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 29, No. 1, 01.01.2009, p. 34-38.

Research output: Contribution to journalArticle

Taguchi, A, Nakagomi, N, Matsuyama, T, Kikuchi-Taura, A, Yoshikawa, H, Kasahara, Y, Hirose, H, Moriwaki, H, Nakagomi, T, Soma, T, Stern, D & Naritomi, H 2009, 'Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction', Journal of Cerebral Blood Flow and Metabolism, vol. 29, no. 1, pp. 34-38. https://doi.org/10.1038/jcbfm.2008.92
Taguchi, Akihiko ; Nakagomi, Nami ; Matsuyama, Tomohiro ; Kikuchi-Taura, Akie ; Yoshikawa, Hiroo ; Kasahara, Yukiko ; Hirose, Haruka ; Moriwaki, Hiroshi ; Nakagomi, Takayuki ; Soma, Toshihiro ; Stern, David ; Naritomi, Hiroaki. / Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction. In: Journal of Cerebral Blood Flow and Metabolism. 2009 ; Vol. 29, No. 1. pp. 34-38.
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