Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment

Akihiko Taguchi, Tomohiro Matsuyama, Takayuki Nakagomi, Yoko Shimizu, Ryuzo Fukunaga, Yoshiaki Tatsumi, Hiroo Yoshikawa, Akie Kikuchi-Taura, Toshihiro Soma, Hiroshi Moriwaki, Kazuyuki Nagatsuka, David Stern, Hiroaki Naritomi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Maintenance of uninterrupted cerebral circulation is critical for neural homeostasis. The level of circulating CD34-positive (CD34+) cells has been suggested as an index of cerebrovascular health, although its relationship with cognitive function has not yet been defined. In a group of individuals with cognitive impairment, the level of circulating CD34+ cells was quantified and correlated with clinical diagnoses. Compared with normal subjects, a significant decrease in circulating CD34+ cells was observed in patients with vascular-type cognitive impairment, although no significant change was observed in patients with Alzheimer's-type cognitive impairment who had no evidence of cerebral ischemia. The level of cognitive impairment was inversely correlated with numbers of circulating CD34+ cells in patients with vascular-type cognitive impairment, but not Alzheimer's type. We propose that the level of circulating CD34+ cells provides a marker of vascular risk associated with cognitive impairment, and that differences in the pathobiology of Alzheimer's- and vascular-type cognitive impairment may be mirrored in levels of circulating CD34+ cells in these patient populations.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume28
Issue number3
DOIs
StatePublished - Mar 1 2008

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Blood Vessels
Cerebrovascular Circulation
Cognitive Dysfunction
Brain Ischemia
Cognition
Homeostasis
Maintenance
Health
Population

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Taguchi, A., Matsuyama, T., Nakagomi, T., Shimizu, Y., Fukunaga, R., Tatsumi, Y., ... Naritomi, H. (2008). Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. Journal of Cerebral Blood Flow and Metabolism, 28(3), 445-449. https://doi.org/10.1038/sj.jcbfm.9600541

Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. / Taguchi, Akihiko; Matsuyama, Tomohiro; Nakagomi, Takayuki; Shimizu, Yoko; Fukunaga, Ryuzo; Tatsumi, Yoshiaki; Yoshikawa, Hiroo; Kikuchi-Taura, Akie; Soma, Toshihiro; Moriwaki, Hiroshi; Nagatsuka, Kazuyuki; Stern, David; Naritomi, Hiroaki.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 28, No. 3, 01.03.2008, p. 445-449.

Research output: Contribution to journalArticle

Taguchi, A, Matsuyama, T, Nakagomi, T, Shimizu, Y, Fukunaga, R, Tatsumi, Y, Yoshikawa, H, Kikuchi-Taura, A, Soma, T, Moriwaki, H, Nagatsuka, K, Stern, D & Naritomi, H 2008, 'Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment', Journal of Cerebral Blood Flow and Metabolism, vol. 28, no. 3, pp. 445-449. https://doi.org/10.1038/sj.jcbfm.9600541
Taguchi, Akihiko ; Matsuyama, Tomohiro ; Nakagomi, Takayuki ; Shimizu, Yoko ; Fukunaga, Ryuzo ; Tatsumi, Yoshiaki ; Yoshikawa, Hiroo ; Kikuchi-Taura, Akie ; Soma, Toshihiro ; Moriwaki, Hiroshi ; Nagatsuka, Kazuyuki ; Stern, David ; Naritomi, Hiroaki. / Circulating CD34-positive cells provide a marker of vascular risk associated with cognitive impairment. In: Journal of Cerebral Blood Flow and Metabolism. 2008 ; Vol. 28, No. 3. pp. 445-449.
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