Circulatory responses of perinatal goats to prostaglandin precursors

T. L. Tyler, Charles Leffler, S. Cassin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of precursors in the prostaglandin synthetic pathway as well as those of analogs of cyclic endoperoxide intermediates upon the pulmonary and systemic circulations of fetal and newborn goats were examined. Exogenous arachidonic acid increased pulmonary vascular resistance and decreased systemic arterial pressure of fetuses and newborns. The effects of dihomo-y-linolenic acid on the circulation are qualitatively similar, but quantitatively less, than those of arachidonic acid. The cyclic endoperoxide analogs were strong pressors in both pulmonary and systemic circulations. The responses to the fatty acid precursors, which are totally blocked by indomethacin and meclofenamate, appear to indicate that they give rise to more than one vasoactive product. Furthermore, exogenous arachidonic acid produces effects which appear to be different from those produced by endogenous pulmonary arachidonic acid.

Original languageEnglish (US)
Pages (from-to)213-229
Number of pages17
JournalProstaglandines and Medicine
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Arachidonic Acid
Goats
Prostaglandins
Pulmonary Circulation
Meclofenamic Acid
Synthetic Prostaglandins
alpha-Linolenic Acid
Indomethacin
Vascular Resistance
Arterial Pressure
Fetus
Fatty Acids
Lung

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Circulatory responses of perinatal goats to prostaglandin precursors. / Tyler, T. L.; Leffler, Charles; Cassin, S.

In: Prostaglandines and Medicine, Vol. 1, No. 3, 01.01.1978, p. 213-229.

Research output: Contribution to journalArticle

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