Clenbuterol reduces soleus muscle fatigue during disuse in aged rats

Kuangjen D. Chen, Stephen Alway

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

High levels of clenbuterol have been shown to preserve muscle mass and function during disuse. In this study we report that a low dose of clenbuterol (10 μg/kg per day) lessened the loss of in situ soleus muscle isometric force normalized to wet muscle weight (Po/g wet weight) by 8% and reduced isometric fatigue by ∼30% in senescent rats after 21 days of hindlimb suspension (HS). Clenbuterol did not reduce the loss of relative force in the soleus of adult rats or the plantaris of old or adult rats. Furthermore, clenbuterol failed to improve muscle force or isometric fatigue in the soleus of adult rats or in the plantaris of either age group after HS. We conclude that low levels of clenbuterol reduce muscle fatigue in slow muscles during disuse and this β-agonist may also have therapeutic value for reducing fatigue in slow muscles (e.g., postural muscles) in the elderly during disuse.

Original languageEnglish (US)
Pages (from-to)211-222
Number of pages12
JournalMuscle and Nerve
Volume24
Issue number2
DOIs
StatePublished - Feb 8 2001
Externally publishedYes

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Clenbuterol
Muscle Fatigue
Skeletal Muscle
Muscles
Hindlimb Suspension
Fatigue
Weights and Measures
Age Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Clenbuterol reduces soleus muscle fatigue during disuse in aged rats. / Chen, Kuangjen D.; Alway, Stephen.

In: Muscle and Nerve, Vol. 24, No. 2, 08.02.2001, p. 211-222.

Research output: Contribution to journalArticle

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