Clinical and molecular insights into tuberous sclerosis complex renal disease

Brian J. Siroky, Hong Yin, John Bissler

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Patients with tuberous sclerosis complex are at great risk of developing renal lesions as part of their disease. These lesions include renal cysts and tumors. Significant advances in understanding the cell biology of these renal lesions has already led to clinical trials demonstrating that pharmacological interventions are likely possible. This review focuses on the pathology of these renal lesions, their underlying cell biology, and the possible therapeutic strategies that may prove to significantly improve care for these patients.

Original languageEnglish (US)
Pages (from-to)839-852
Number of pages14
JournalPediatric Nephrology
Volume26
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Tuberous Sclerosis
Kidney
Cell Biology
Cysts
Patient Care
Clinical Trials
Pharmacology
Pathology
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Clinical and molecular insights into tuberous sclerosis complex renal disease. / Siroky, Brian J.; Yin, Hong; Bissler, John.

In: Pediatric Nephrology, Vol. 26, No. 6, 01.06.2011, p. 839-852.

Research output: Contribution to journalReview article

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