Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding

Frederick A. Moore, Ernest E. Moore, Kenneth A. Kudsk, Rex Brown, Robert H. Bower, Mark J. Koruda, Christopher C. Baker, Adrian Barbul

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

In this multicenter prospective controlled trial, 98 evaluable patients sustaining major torso trauma were randomized to receive early enteral nutrition with a new “immune-enhancing” diet (study: N = 51) or a standard stress enteral formula (control: N = 47). At baseline, both groups had comparable demographics and Injury Severity Scores. After 7 days of feeding, the groups had equivalent increases in serum total protein, albumin, and transferrin concentrations. Patients receiving the “immune-enhancing” diet, however, experienced significantly greater increases in total lymphocyte (p = 0.014), T lymphocyte (p = 0.04), and T-helper (p = 0.004) cell numbers. Additionally, these patients had significantly fewer intraabdominal abscesses (study, 0% vs. control, 11%; p = 0.023) and significantly less multiple organ failure (study, 0% vs. control, 11%;p = 0.023). In conclusion, this multicenter trial suggests this "immune-enhancing" enteral diet offers clinical benefits in stressed surgical patients.

Original languageEnglish (US)
Pages (from-to)607-615
Number of pages9
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume37
Issue number4
DOIs
StatePublished - Jan 1 1994

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Enteral Nutrition
Diet
Small Intestine
Torso
Injury Severity Score
Multiple Organ Failure
Transferrin
Abscess
Multicenter Studies
Blood Proteins
Albumins
Cell Count
Demography
Lymphocytes
T-Lymphocytes
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Moore, F. A., Moore, E. E., Kudsk, K. A., Brown, R., Bower, R. H., Koruda, M. J., ... Barbul, A. (1994). Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. Journal of Trauma - Injury, Infection and Critical Care, 37(4), 607-615. https://doi.org/10.1097/00005373-199410000-00014

Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. / Moore, Frederick A.; Moore, Ernest E.; Kudsk, Kenneth A.; Brown, Rex; Bower, Robert H.; Koruda, Mark J.; Baker, Christopher C.; Barbul, Adrian.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 37, No. 4, 01.01.1994, p. 607-615.

Research output: Contribution to journalArticle

Moore, FA, Moore, EE, Kudsk, KA, Brown, R, Bower, RH, Koruda, MJ, Baker, CC & Barbul, A 1994, 'Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding', Journal of Trauma - Injury, Infection and Critical Care, vol. 37, no. 4, pp. 607-615. https://doi.org/10.1097/00005373-199410000-00014
Moore, Frederick A. ; Moore, Ernest E. ; Kudsk, Kenneth A. ; Brown, Rex ; Bower, Robert H. ; Koruda, Mark J. ; Baker, Christopher C. ; Barbul, Adrian. / Clinical benefits of an immune-enhancing diet for early postinjury enteral feeding. In: Journal of Trauma - Injury, Infection and Critical Care. 1994 ; Vol. 37, No. 4. pp. 607-615.
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